Literature DB >> 826977

Piperidine: effects on locomotor activity and brain monoamine turnover.

B Alm.   

Abstract

The effects of piperidine HCl (PHCl) on locomotor activity, flexor reflex activity and monoamine levels, turnover, and synthesis were studied. Results indicate a sedative action and an increased turnover of noradrenaline (NA), but no effects on 5-hydroxytryptamine (5-HT) or dopamine (DA). Data obtained from flexor reflex experiments suggest that this is not secondary to alpha-adrenergic receptor blockade. One explanation might be an increased impulse activity of NA neurons, but the exact mechanism remains to be elucidated.

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Year:  1976        PMID： 826977     DOI： 10.1007/BF00426848

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  32 in total

1.  AMINE CONTENT OF NORMAL HUMAN CEREBROSPINAL FLUID.

Authors:  T L PERRY; S HANSEN; L C JENKINS
Journal:  J Neurochem       Date:  1964-01       Impact factor: 5.372

2.  Some pharmacological actions of piperidine, pyrrolidine, and of pressor concentrates from dog urine.

Authors:  M F LOCKETT
Journal:  Br J Pharmacol Chemother       Date:  1949-06

3.  The occurrence and determination of piperidine in human and animal urine.

Authors:  U S von EULER
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1945

4.  Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase.

Authors:  A Carlsson; J N Davis; W Kehr; M Lindqvist; C V Atack
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

Review 5.  Drugs and sleep.

Authors:  I Oswald
Journal:  Pharmacol Rev       Date:  1968-12       Impact factor: 25.468

6.  The production of piperidine from pipecolic acid in the rat brain.

Authors:  Y Kasé; Y Okano; T Miyata; M Kataoka; N Yonehara
Journal:  Life Sci       Date:  1974-02-16       Impact factor: 5.037

7.  The determination of dopamine by a modification of the dihydroxyindole fluorimetric assay.

Authors:  C V Atack
Journal:  Br J Pharmacol       Date:  1973-08       Impact factor: 8.739

8.  An improved method for determination of micro amounts of piperidine in living materials.

Authors:  Y Kase; M Kataoka; T Miyata
Journal:  Jpn J Pharmacol       Date:  1969-09

9.  Piperidine in the cerebellum of the dog.

Authors:  M Kataoka; Y Kasé; T Miyata; E Kawahito
Journal:  J Neurochem       Date:  1970-02       Impact factor: 5.372

10.  Reduction of the monoamine stores in the terminals of bulbospinal neurones following stimulation in the medulla oblongata.

Authors:  A Dahlström; K Fuxe; D Kernell; G Sedvall
Journal:  Life Sci       Date:  1965-06       Impact factor: 5.037
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  2 in total

1.  Voltage clamp analysis of the kinetics of piperidine-induced chloride current in isolated Aplysia neurons.

Authors:  K Takahama; M R Klee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-11       Impact factor: 3.000

2.  Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation.

Authors:  Anil K Singh; Sumit Rathore; Yan Tang; Nathan E Goldfarb; Ben M Dunn; Vinoth Rajendran; Prahlad C Ghosh; Neelu Singh; N Latha; Brajendra K Singh; Manmeet Rawat; Brijesh Rathi
Journal:  PLoS One       Date:  2015-10-26       Impact factor: 3.240
  2 in total

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