A V Panfilov1, J P Keener. 1. Department of Mathematics, University of Utah, Salt Lake City.
Abstract
INTRODUCTION: We investigated numerically the effects of the rotation of fiber axis orientation through the myocardial wall on wave propagation. METHODS AND RESULTS: We show that because of this rotation and inherent discrete properties of myocardium, a premature stimulus can create unidirectional conduction block leading to reentry. CONCLUSION: The dynamics of the subsequent reentrant patterns are complicated by the presence of rotational anisotropy, as the center of reentry drifts, and the reentry terminates in finite time when it collides with the domain boundary.
INTRODUCTION: We investigated numerically the effects of the rotation of fiber axis orientation through the myocardial wall on wave propagation. METHODS AND RESULTS: We show that because of this rotation and inherent discrete properties of myocardium, a premature stimulus can create unidirectional conduction block leading to reentry. CONCLUSION: The dynamics of the subsequent reentrant patterns are complicated by the presence of rotational anisotropy, as the center of reentry drifts, and the reentry terminates in finite time when it collides with the domain boundary.
Authors: Sergey F Pravdin; Hans Dierckx; Leonid B Katsnelson; Olga Solovyova; Vladimir S Markhasin; Alexander V Panfilov Journal: PLoS One Date: 2014-05-09 Impact factor: 3.240
Authors: James Southern; Joe Pitt-Francis; Jonathan Whiteley; Daniel Stokeley; Hiromichi Kobashi; Ross Nobes; Yoshimasa Kadooka; David Gavaghan Journal: Prog Biophys Mol Biol Date: 2007-08-11 Impact factor: 3.667