Literature DB >> 8266105

WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

D A Haber1, S Park, S Maheswaran, C Englert, G G Re, D J Hazen-Martin, D A Sens, A J Garvin.   

Abstract

A human Wilms tumor cell line (RM1) was developed to test the tumor suppressor activity of WT1, a zinc finger transcription factor that is expressed in the developing human kidney and is mutationally inactivated in a subset of Wilms tumors. Transfection of each of four wild-type WT1 isoforms suppressed the growth of RM1 cells. The endogenous WT1 transcript in these cells was devoid of exon 2 sequences, a splicing alteration that was also detected in varying amounts in all Wilms tumors tested but not in normal kidney. Production of this abnormal transcript, which encodes a functionally altered protein, may represent a distinct mechanism for inactivating WT1 in Wilms tumors.

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Year:  1993        PMID： 8266105     DOI： 10.1126/science.8266105

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  35 in total

Review 1.  Wilms' tumor gene WT1: its oncogenic function and clinical application.

Authors:  H Sugiyama
Journal:  Int J Hematol       Date:  2001-02       Impact factor: 2.490

2.  Ikaros induces quiescence and T-cell differentiation in a leukemia cell line.

Authors:  Katie L Kathrein; Rachelle Lorenz; Angela Minniti Innes; Erin Griffiths; Susan Winandy
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

3.  An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.

Authors:  Marianne K-H Kim; Thomas J McGarry; Pilib O Broin; Jared M Flatow; Aaron A-J Golden; Jonathan D Licht
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-22       Impact factor: 11.205

4.  Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.

Authors:  S Maheswaran; C Englert; G Zheng; S B Lee; J Wong; D P Harkin; J Bean; R Ezzell; A J Garvin; R T McCluskey; J A DeCaprio; D A Haber
Journal:  Genes Dev       Date:  1998-04-15       Impact factor: 11.361

5.  A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.

Authors:  R W Johnstone; R H See; S F Sells; J Wang; S Muthukkumar; C Englert; D A Haber; J D Licht; S P Sugrue; T Roberts; V M Rangnekar; Y Shi
Journal:  Mol Cell Biol       Date:  1996-12       Impact factor: 4.272

6.  Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding.

Authors:  Q Zhan; I T Chen; M J Antinore; A J Fornace
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

7.  The role of NF-kappaB in the regulation of the expression of wilms tumor suppressor gene WT1.

Authors:  Y Chen; B R Williams
Journal:  Gene Expr       Date:  2000

8.  Expression and function of the leucine zipper protein Par-4 in apoptosis.

Authors:  S F Sells; S S Han; S Muthukkumar; N Maddiwar; R Johnstone; E Boghaert; D Gillis; G Liu; P Nair; S Monnig; P Collini; M P Mattson; V P Sukhatme; S G Zimmer; D P Wood; J W McRoberts; Y Shi; V M Rangnekar
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

9.  High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas.

Authors:  A B Bianchi; S I Mitsunaga; J Q Cheng; W M Klein; S C Jhanwar; B Seizinger; N Kley; A J Klein-Szanto; J R Testa
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

10.  The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.

Authors:  Dagmar Wilhelm; Christoph Englert
Journal:  Genes Dev       Date:  2002-07-15       Impact factor: 11.361
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