Literature DB >> 8266081

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.

A Shrivastava1, S Saleque, G V Kalpana, S Artandi, S P Goff, K Calame.   

Abstract

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

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Year:  1993        PMID： 8266081     DOI： 10.1126/science.8266081

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  92 in total

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4.  The nuclear matrix protein NMP-1 is the transcription factor YY1.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

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Review 6.  Regulation of serum amyloid A protein expression during the acute-phase response.

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7.  Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis.

Authors:  B Lutterbach; S R Hann
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8.  Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.

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9.  Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.

Authors:  M E Miller; B R Cairns; R S Levinson; K R Yamamoto; D A Engel; M M Smith
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10.  Influence of promoter potency on the transcriptional effects of YY1, SRF and Msx-1 in transient transfection analysis.

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