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Literature DB >> 8265592

Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture.

Abstract

We have developed a quantitative description for calcium permeability of the N-methyl-D-aspartate receptor channel to permit predictions of the reversal potential and calcium influx at different voltages for different extracellular calcium concentrations. Increasing the external calcium concentration markedly shifted the reversal potential to positive values and simultaneously decreased the single-channel conductance at potentials negative to the reversal potential. Very simple quantitative descriptions of calcium permeation and channel block by calcium ions accurately characterize our data and permit the prediction of reversal potentials and magnitudes of calcium influx for a wide range of conditions.

Entities: Chemical

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Year: 1993 PMID： 8265592 PMCID： PMC48026 DOI： 10.1073/pnas.90.24.11573

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

1. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex.

Authors: G Carmignoto; S Vicini
Journal: Science Date: 1992-11-06 Impact factor: 47.728

Review 2. Developmental regulation of nicotinic acetylcholine receptors.

Authors: S M Schuetze; L W Role
Journal: Annu Rev Neurosci Date: 1987 Impact factor: 12.449

Review 3. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.

Authors: D W Choi; S M Rothman
Journal: Annu Rev Neurosci Date: 1990 Impact factor: 12.449

4. Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones.

Authors: I D Forsythe; G L Westbrook
Journal: J Physiol Date: 1988-02 Impact factor: 5.182

5. Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.

Authors: R C Malenka; J A Kauer; R S Zucker; R A Nicoll
Journal: Science Date: 1988-10-07 Impact factor: 47.728

6. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

Authors: M Iino; S Ozawa; K Tsuzuki
Journal: J Physiol Date: 1990-05 Impact factor: 5.182

7. Identification by mutagenesis of a Mg(2+)-block site of the NMDA receptor channel.

Authors: H Mori; H Masaki; T Yamakura; M Mishina
Journal: Nature Date: 1992-08-20 Impact factor: 49.962

8. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor.

Authors: N Burnashev; R Schoepfer; H Monyer; J P Ruppersberg; W Günther; P H Seeburg; B Sakmann
Journal: Science Date: 1992-09-04 Impact factor: 47.728

9. Ionic dependence of glutamate neurotoxicity.

Authors: D W Choi
Journal: J Neurosci Date: 1987-02 Impact factor: 6.167

10. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture.

Authors: P Ascher; L Nowak
Journal: J Physiol Date: 1988-05 Impact factor: 5.182

69 in total

1. Permeant ion regulation of N-methyl-D-aspartate receptor channel block by Mg(2+).

Authors: S M Antonov; J W Johnson
Journal: Proc Natl Acad Sci U S A Date: 1999-12-07 Impact factor: 11.205

2. Ca(2+)-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses.

Authors: J Rohrbough; N C Spitzer
Journal: J Neurosci Date: 1999-10-01 Impact factor: 6.167

10. Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones.

Authors: O Garaschuk; R Schneggenburger; C Schirra; F Tempia; A Konnerth
Journal: J Physiol Date: 1996-03-15 Impact factor: 5.182

Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture.

1. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex.

Review 2. Developmental regulation of nicotinic acetylcholine receptors.

Review 3. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.

4. Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones.

5. Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.

6. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

7. Identification by mutagenesis of a Mg(2+)-block site of the NMDA receptor channel.

8. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor.

9. Ionic dependence of glutamate neurotoxicity.

10. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture.

1. Permeant ion regulation of N-methyl-D-aspartate receptor channel block by Mg(2+).

2. Ca(2+)-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses.

3. A calcium-dependent feedback mechanism participates in shaping single NMDA miniature EPSCs.

4. Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses.

5. Developmental profile of the changing properties of NMDA receptors at cerebellar mossy fiber-granule cell synapses.

6. NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).

7. Ca(2+) conduction by an amino acid-gated ion channel related to glutamate receptors.

8. Ca2+ influx amplifies protein kinase C potentiation of recombinant NMDA receptors.

Review 9. Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine.

10. Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones.