Literature DB >> 8264675

Construction of a genetic map telomeric to HLA-A by microsatellite analysis.

C Camaschella1, A Roetto, G De Sandre, A Piperno, A Totaro, I Dianzani, P Gasparini.   

Abstract

Allele and genotype frequencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types--available for all the studied samples--allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage analysis of genetic disorders mapping on this region of 6p.

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Year:  1993        PMID： 8264675     DOI： 10.1006/mcpr.1993.1060

Source DB:  PubMed          Journal:  Mol Cell Probes        ISSN： 0890-8508            Impact factor:   2.365


  3 in total

1.  New polymorphisms and markers in the HLA class I region: relevance to hereditary hemochromatosis (HFE).

Authors:  A Totaro; A Grifa; A Roetto; C Lunardi; L D'Agruma; L Sbaiz; L Zelante; G De Sandre; C Camaschella; P Gasparini
Journal:  Hum Genet       Date:  1995-04       Impact factor: 4.132

2.  The motilin gene: subregional localisation, tissue expression, DNA polymorphisms and exclusion as a candidate gene for the HLA-associated immotile cilia syndrome.

Authors:  P Gasparini; A Grifa; S Savasta; I Merlo; L Bisceglia; A Totaro; L Zelante
Journal:  Hum Genet       Date:  1994-12       Impact factor: 4.132

3.  Allelic association of microsatellites of 6p in Italian hemochromatosis patients.

Authors:  C Camaschella; A Roetto; P Gasparini; A Piperno; P Fortina; S Surrey; E Rappaport
Journal:  Hum Genet       Date:  1996-04       Impact factor: 4.132
  3 in total

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