H Rusinek1, R Chandra. 1. Department of Radiology, New York University Medical Center, NY 10016.
Abstract
RATIONALE AND OBJECTIVES: The authors appraised the accuracy of a method for brain volume measurement from magnetic resonance images and evaluated the effects of the acquisition matrix, slice thickness, and tissue sampling on the measurement error. METHODS: The method uses two magnetic resonance imaging sequences to account explicitly for partial volume effects. The accuracy was measured with one-, two-, and three-compartmental phantoms that mimic the relaxation properties of brain tissues. The sensitivity of the method to section thickness was measured by repeated scans of human brain. RESULTS: Using a strongly T2-weighted sequence and two-compartmental phantoms, the average error was 5%, with 3% error for phantoms larger than 90 mL. In the three-compartmental phantoms the error varied from 2% to 7%. Varying the section thickness from 5 to 10 mm on three-compartmental phantoms and from 2.5 to 10 mm in the human brain did not significantly affect compartmental volumes. CONCLUSIONS: The experimental study validates the feasibility of monitoring localized volume changes in a three-compartmental model.
RATIONALE AND OBJECTIVES: The authors appraised the accuracy of a method for brain volume measurement from magnetic resonance images and evaluated the effects of the acquisition matrix, slice thickness, and tissue sampling on the measurement error. METHODS: The method uses two magnetic resonance imaging sequences to account explicitly for partial volume effects. The accuracy was measured with one-, two-, and three-compartmental phantoms that mimic the relaxation properties of brain tissues. The sensitivity of the method to section thickness was measured by repeated scans of human brain. RESULTS: Using a strongly T2-weighted sequence and two-compartmental phantoms, the average error was 5%, with 3% error for phantoms larger than 90 mL. In the three-compartmental phantoms the error varied from 2% to 7%. Varying the section thickness from 5 to 10 mm on three-compartmental phantoms and from 2.5 to 10 mm in the human brain did not significantly affect compartmental volumes. CONCLUSIONS: The experimental study validates the feasibility of monitoring localized volume changes in a three-compartmental model.
Authors: Lisa Mosconi; Susan De Santi; Juan Li; Wai Hon Tsui; Yi Li; Madhu Boppana; Eugene Laska; Henry Rusinek; Mony J de Leon Journal: Neurobiol Aging Date: 2007-01-11 Impact factor: 4.673
Authors: P L Davis; M J Staiger; K B Harris; M A Ganott; J Klementaviciene; K S McCarty; H Tobon Journal: Breast Cancer Res Treat Date: 1996 Impact factor: 4.872
Authors: Matilde Inglese; Henry Rusinek; Ilena C George; James S Babb; Robert I Grossman; Oded Gonen Journal: Neuroimage Date: 2008-03-04 Impact factor: 6.556
Authors: Lidia Glodzik; William E Wu; James S Babb; Lutz Achtnichts; Michael Amann; Marc Sollberger; Andreas U Monsch; Achim Gass; Oded Gonen Journal: Psychiatry Res Date: 2012-10-30 Impact factor: 3.222