Literature DB >> 8262737

Phase II trial of piroxantrone in patients with recurrent and metastatic squamous cell carcinoma of the head and neck. A Southwest Oncology Group trial.

S A Taylor1, J Benedetti, D Schuller, S P Richman, G O Broun, A Hantel.   

Abstract

Twenty-two patients with recurrent or metastatic squamous cell carcinoma of the head and neck were treated with piroxantrone 150 mg/m2 intravenously every 21 days. There were no objective responses. The 95% upper confidence bound for response is 15%. Primary toxicity was hematologic.

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Year:  1993        PMID: 8262737     DOI: 10.1007/bf00874161

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN: 0167-6997            Impact factor:   3.850


  2 in total

1.  Phase I and clinical pharmacological evaluation of pirozantrone hydrochloride (oxantrazole).

Authors:  M M Ames; C L Loprinzi; J M Collins; C van Haelst-Pisani; R L Richardson; J Rubin; C G Moertel
Journal:  Cancer Res       Date:  1990-07-01       Impact factor: 12.701

2.  5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation.

Authors:  H D Showalter; J L Johnson; L M Werbel; W R Leopold; R C Jackson; E F Elslager
Journal:  J Med Chem       Date:  1984-03       Impact factor: 7.446

  2 in total

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