Literature DB >> 8262230

Modulation of functional activities of the neurotoxin from black widow spider venom.

E V Grishin1, N H Himmelreich, K A Pluzhnikov, N G Pozdnyakova, L G Storchak, T M Volkova, P G Woll.   

Abstract

We have studied the action of an alpha-latrotoxin (alpha-LTX) complex of two polypeptides (LTX 130 kDa and low molecular weight protein (LMWP) 8 kDa) and the action of a venom fraction containing LTX with excess LMWP on calcium influx into synaptosomes and PC12 cells as well as on [14C]GABA release from synaptosomes. Both preparations considerably activate calcium influx and stimulate [14C]GABA release from synaptosomes. Preincubation of both preparations with antibodies against a 14 amino acid residue C-terminal peptide of LMWP differentially modulates these effects. Antibodies inhibit induced calcium influx and enhance induced GABA release.

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Year:  1993        PMID： 8262230     DOI： 10.1016/0014-5793(93)80803-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Recruitment and diversification of an ecdysozoan family of neuropeptide hormones for black widow spider venom expression.

Authors:  Caryn McCowan; Jessica E Garb
Journal:  Gene       Date:  2013-12-05       Impact factor: 3.688

2.  alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.

Authors:  K Ichtchenko; M Khvotchev; N Kiyatkin; L Simpson; S Sugita; T C Südhof
Journal:  EMBO J       Date:  1998-11-02       Impact factor: 11.598

Review 3.  Insecticidal toxins from black widow spider venom.

Authors:  A Rohou; J Nield; Y A Ushkaryov
Journal:  Toxicon       Date:  2006-11-30       Impact factor: 3.033

4.  Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva.

Authors:  Francielle A Cordeiro; Fernanda G Amorim; Fernando A P Anjolette; Eliane C Arantes
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2015-08-13

5.  House spider genome uncovers evolutionary shifts in the diversity and expression of black widow venom proteins associated with extreme toxicity.

Authors:  Kerry L Gendreau; Robert A Haney; Evelyn E Schwager; Torsten Wierschin; Mario Stanke; Stephen Richards; Jessica E Garb
Journal:  BMC Genomics       Date:  2017-02-16       Impact factor: 3.969

6.  Pore-Forming Proteins from Cnidarians and Arachnids as Potential Biotechnological Tools.

Authors:  Esperanza Rivera-de-Torre; Juan Palacios-Ortega; José G Gavilanes; Álvaro Martínez-Del-Pozo; Sara García-Linares
Journal:  Toxins (Basel)       Date:  2019-06-25       Impact factor: 4.546

Review 7.  alpha-Latrotoxin and its receptors.

Authors:  Yuri A Ushkaryov; Alexis Rohou; Shuzo Sugita
Journal:  Handb Exp Pharmacol       Date:  2008

Review 8.  Recent Advances in Research on Widow Spider Venoms and Toxins.

Authors:  Shuai Yan; Xianchun Wang
Journal:  Toxins (Basel)       Date:  2015-11-27       Impact factor: 4.546

Review 9.  Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses.

Authors:  Nicolas Langenegger; Wolfgang Nentwig; Lucia Kuhn-Nentwig
Journal:  Toxins (Basel)       Date:  2019-10-22       Impact factor: 4.546
  9 in total

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