Literature DB >> 8262218

Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4.

J W Creemers1, P J Groot Kormelink, A J Roebroek, K Nakayama, W J Van de Ven.   

Abstract

Proprotein processing activity of the Kex2-like mammalian endoprotease PACE4 and its cleavage selectivity for sites with basic amino acid residues were determined. Using a recombinant vaccinia virus-based expression system, PACE4 was expressed in pig kidney PK(15) cells and, like two other Kex2-like endoproteases furin and PC6A, shown to correctly process the precursor of von Willebrand factor (pro-vWF). Furthermore, characteristics of the cleavage site selectivity of PACE4 were compared to those of furin and PC6A using the vWF cleavage site mutants vWFR-1G, vWFK-2A, and vWFR-4A as substrates. Cleavage site selectivity of PACE4 and PC6A appeared to be similar but they differed from that of furin.

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Year:  1993        PMID： 8262218     DOI： 10.1016/0014-5793(93)81610-c

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Molecular Validation of PACE4 as a Target in Prostate Cancer.

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Journal:  Transl Oncol       Date:  2011-06-01       Impact factor: 4.243

2.  PACE4: a subtilisin-like endoprotease with unique properties.

Authors:  R E Mains; C A Berard; J B Denault; A Zhou; R C Johnson; R Leduc
Journal:  Biochem J       Date:  1997-02-01       Impact factor: 3.857

3.  A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.

Authors:  V M Gordon; A Rehemtulla; S H Leppla
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

4.  The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.

Authors:  Qiang Li; Xianghua Liu; Yanhua Wu; Jian An; Saiyin Hexige; Yichen Ling; Mingjun Zhang; Xianmei Yang; Long Yu
Journal:  Mol Cell Biochem       Date:  2011-07-30       Impact factor: 3.396

5.  Identification of the cleavage sites in the alpha6A integrin subunit: structural requirements for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrin.

Authors:  G O Delwel; I Kuikman; R C van der Schors; A A de Melker; A Sonnenberg
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

6.  The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells.

Authors:  S Hallenberger; M Moulard; M Sordel; H D Klenk; W Garten
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

7.  Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.

Authors:  T Horimoto; K Nakayama; S P Smeekens; Y Kawaoka
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103

8.  Generation and characterization of non-competitive furin-inhibiting nanobodies.

Authors:  Jingjing Zhu; Jeroen Declercq; Bart Roucourt; Gholamreza H Ghassabeh; Sandra Meulemans; Jörg Kinne; Guido David; Alphons J M Vermorken; Wim J M Van de Ven; Iris Lindberg; Serge Muyldermans; John W M Creemers
Journal:  Biochem J       Date:  2012-11-15       Impact factor: 3.857

9.  Proprotein convertases process Pmel17 during secretion.

Authors:  Ralf M Leonhardt; Nathalie Vigneron; Christoph Rahner; Peter Cresswell
Journal:  J Biol Chem       Date:  2011-01-19       Impact factor: 5.157

10.  Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.

Authors:  J F Sucic; J M Moehring; N M Inocencio; J W Luchini; T J Moehring
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.766
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