Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

Literature DB >> 8262066

The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

Abstract

The beta 1 and beta 2 subunits are the closely-related large chains of the trans-Golgi network AP-1 and the plasma membrane AP-2 clathrin-associated protein complexes, respectively. Recombinant beta 1 and beta 2 subunits have been generated in Escherichia coli. It was found that, in the absence of all the other AP subunits, beta 1 and beta 2 interact with clathrin and drive the efficient assembly of clathrin coats. In addition, beta 2 subunits and AP complexes compete for the same clathrin binding site. The appearance of the clathrin/beta coats is the same as the barrel-shaped structures formed with native AP complexes. It is proposed that the principal function of the beta subunits is to initiate coat formation, while the remaining subunits of the AP complexes have other roles in coated pit and coated vesicle function.

Entities: Chemical

Mesh：

Substances：

Year: 1993 PMID： 8262066 PMCID： PMC413789 DOI： 10.1002/j.1460-2075.1993.tb06219.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

38 in total

1. Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2.

Authors: W Matsui; T Kirchhausen
Journal: Biochemistry Date: 1990-12-04 Impact factor: 3.162

2. Self-association of the plasma membrane-associated clathrin assembly protein AP-2.

Authors: K A Beck; J H Keen
Journal: J Biol Chem Date: 1991-03-05 Impact factor: 5.157

Review 3. Clathrin, adaptors, and sorting.

Authors: B M Pearse; M S Robinson
Journal: Annu Rev Cell Biol Date: 1990

4. Use of T7 RNA polymerase to direct expression of cloned genes.

Authors: F W Studier; A H Rosenberg; J J Dunn; J W Dubendorff
Journal: Methods Enzymol Date: 1990 Impact factor: 1.600

5. Identification of a clathrin binding subunit in the HA2 adaptor protein complex.

Authors: S Ahle; E Ungewickell
Journal: J Biol Chem Date: 1989-11-25 Impact factor: 5.157

6. Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.

Authors: T Kirchhausen; K L Nathanson; W Matsui; A Vaisberg; E P Chow; C Burne; J H Keen; A E Davis
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

7. Identification of the clathrin-binding domain of assembly protein AP-2.

Authors: J H Keen; K A Beck
Journal: Biochem Biophys Res Commun Date: 1989-01-16 Impact factor: 3.575

8. Receptors compete for adaptors found in plasma membrane coated pits.

Authors: B M Pearse
Journal: EMBO J Date: 1988-11 Impact factor: 11.598

9. Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

Authors: J N Glickman; E Conibear; B M Pearse
Journal: EMBO J Date: 1989-04 Impact factor: 11.598

10. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus.

Authors: M S Robinson
Journal: J Cell Biol Date: 1990-12 Impact factor: 10.539

49 in total

1. Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.

Authors: A Nesterov; R E Carter; T Sorkina; G N Gill; A Sorkin
Journal: EMBO J Date: 1999-05-04 Impact factor: 11.598

10. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.

Authors: A Mangasarian; V Piguet; J K Wang; Y L Chen; D Trono
Journal: J Virol Date: 1999-03 Impact factor: 5.103

The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

1. Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2.

2. Self-association of the plasma membrane-associated clathrin assembly protein AP-2.

Review 3. Clathrin, adaptors, and sorting.

4. Use of T7 RNA polymerase to direct expression of cloned genes.

5. Identification of a clathrin binding subunit in the HA2 adaptor protein complex.

6. Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.

7. Identification of the clathrin-binding domain of assembly protein AP-2.

8. Receptors compete for adaptors found in plasma membrane coated pits.

9. Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

10. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus.

1. Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.

2. Crystal structure of the clathrin adaptor protein 1 core.

3. Altered renal proximal tubular endocytosis and histology in mice lacking myosin-VI.

Review 4. The molecular characterization of transport vesicles.

Review 5. Molecular aspects of the endocytic pathway.

6. Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.

7. Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptors.

8. Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.

9. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.

10. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.