| Literature DB >> 8261128 |
A Khateb1, P Fort, A Alonso, B E Jones, M Mühlethaler.
Abstract
Identified electrophysiologically by low threshold bursts and transient outward rectification, cholinergic nucleus basalis neurons were recorded and labelled intracellularly in guinea-pig basal forebrain slices. By means of a triple labelling immunofluorescent technique, serotonin-immunoreactive fibres were visualized in close proximity to the soma and dendrites of the biocytin-labelled, choline acetyl transferase (ChAT)-immunoreactive cells. By bath application, 5-hydroxytryptamine (5-HT) produced a direct hyperpolarization of the identified cells which was mimicked by 5-HT1A receptor agonists, suggesting that it may inhibit the tonic firing but also modulate the low threshold bursting of the cholinergic nucleus basalis neurons.Entities:
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Year: 1993 PMID： 8261128 DOI： 10.1111/j.1460-9568.1993.tb00519.x
Source DB: PubMed Journal: Eur J Neurosci ISSN： 0953-816X Impact factor: 3.386