Literature DB >> 8260599

Cloning and characterization of the tandemly arranged bovine lymphotoxin and tumour necrosis factor-alpha genes.

I Cludts1, Y Cleuter, R Kettmann, A Burny, L Droogmans.   

Abstract

The screening of a bovine genomic library with a human tumour necrosis factor-alpha (TNF-alpha) cDNA probe resulted in the isolation of a 7.2 kb DNA fragment containing the entire bovine TNF-alpha gene. Analysis of this genomic clone showed that it also contains the bovine lymphotoxin (LT, TNF-beta) gene. Comparison to published sequences of human, murine, ovine and rabbit counterparts allowed us to delineate the coding sequences, the promoters and the enhancers of these two genes. Sequences involved in the regulation of translation and in the mRNA stability were found in the 3' untranslated regions.

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Year:  1993        PMID： 8260599     DOI： 10.1016/1043-4666(93)90065-d

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  6 in total

1.  Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha.

Authors:  B Mertens; C Muriuki; L Gaidulis
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

2.  The use of denaturing gradient gel electrophoresis in mapping the bovine tumor necrosis factor alpha gene locus.

Authors:  D H Lester; G C Russell; W Barendse; J L Williams
Journal:  Mamm Genome       Date:  1996-03       Impact factor: 2.957

3.  Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum.

Authors:  C R Wyatt; E J Brackett; L E Perryman; A C Rice-Ficht; W C Brown; K I O'Rourke
Journal:  Infect Immun       Date:  1997-01       Impact factor: 3.441

4.  Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23.

Authors:  M Agaba; S J Kemp; W Barendse; A J Teale
Journal:  Mamm Genome       Date:  1996-03       Impact factor: 2.957

5.  A low-molecular-weight fraction of bovine colostrum and milk enhances the oxidative burst activity of polymorphonuclear leukocytes.

Authors:  H Sugisawa; T Itou; M Saito; T Moritomo; Y Miura; T Sakai
Journal:  Vet Res Commun       Date:  2003-09       Impact factor: 2.459

6.  Tumor necrosis factor-alpha (TNF-alpha) inhibits steroidogenesis of bovine ovarian granulosa and thecal cells in vitro. Involvement of TNF-alpha receptors.

Authors:  L J Spicer
Journal:  Endocrine       Date:  1998-04       Impact factor: 3.925
  6 in total

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