Literature DB >> 8259923

Altered nucleosome spacing associated with Down syndrome.

N H Kahmann1, A V Rake.   

Abstract

Micrococcal nuclease digestions of human leukocytes were analyzed using gel electrophoresis. The relative size (or average number of nucleotides) of nucleosomes was determined. The mean nucleosome size of the normal 46 chromosome karyotype is 185 +/- 2 bp. There was no significant variation in nucleosome size within the normal population due to age, sex, or race. The mean nucleosome size of the Down syndrome samples is 173 +/- 3 bp. These two groups have separate normal distribution curves which do not overlap and are significantly different at P < 0.1%.

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Year:  1993        PMID： 8259923     DOI： 10.1007/bf00557329

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  8 in total

1.  The efficient separation of lymphocytes from normal human blood.

Authors:  B CASSEN; J HITT; E F HAYS
Journal:  J Lab Clin Med       Date:  1958-11

2.  Nucleosome unit repeat size in aneuploid mice.

Authors:  A V Rake
Journal:  Biochem Genet       Date:  1990-08       Impact factor: 1.890

3.  Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16.

Authors:  J Pash; N Popescu; M Matocha; S Rapoport; M Bustin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

4.  Effect of a partial trisomy in the mouse upon cellular and nuclear RNA.

Authors:  A V Rake; B Patel; M De Leon
Journal:  Biochem Genet       Date:  1989-08       Impact factor: 1.890

5.  Altered chromatin structure associated with a partial trisomy of chromosome 7 in the mouse.

Authors:  A V Rake; R H Edwards
Journal:  Biochem Genet       Date:  1987-10       Impact factor: 1.890

6.  The structure of the human cell interphase chromatin in the mosaic form of Down's disease.

Authors:  K N Fedorova
Journal:  J Ment Defic Res       Date:  1977-06

7.  Transcribed chromatin exhibits an altered nucleosomal spacing.

Authors:  R D Smith; R L Seale; J Yu
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Lymphocyte interphase chromatin in healthy subjects, patients with Down's syndrome, and their parents and sibs.

Authors:  K N Fedorova; I E Yudina
Journal:  J Med Genet       Date:  1982-12       Impact factor: 6.318
  8 in total
  3 in total

1.  Role of long non-coding RNAs in Down syndrome patients: a transcriptome analysis study.

Authors:  Michele Salemi; Rossella Cannarella; Giovanna Marchese; Maria Grazia Salluzzo; Maria Ravo; Concetta Barone; Mariangela Lo Giudice; Aldo E Calogero; Corrado Romano
Journal:  Hum Cell       Date:  2021-09-12       Impact factor: 4.374

2.  Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.

Authors:  Cody T Mowery; Jaime M Reyes; Lucia Cabal-Hierro; Kelly J Higby; Kristen L Karlin; Jarey H Wang; Robert J Kimmerling; Paloma Cejas; Klothilda Lim; Hubo Li; Takashi Furusawa; Henry W Long; David Pellman; Bjoern Chapuy; Michael Bustin; Scott R Manalis; Thomas F Westbrook; Charles Y Lin; Andrew A Lane
Journal:  Cell Rep       Date:  2018-11-13       Impact factor: 9.423

3.  Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.

Authors:  Alejandra Rodríguez-Ortiz; Julio César Montoya-Villegas; Felipe García-Vallejo; Yecid Mina-Paz
Journal:  Genes (Basel)       Date:  2021-12-17       Impact factor: 4.096
  3 in total

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