Literature DB >> 8259136

A possible role for the 3'-untranslated region in developmental regulation in Trypanosoma brucei.

M Hug1, V B Carruthers, C Hartmann, D S Sherman, G A Cross, C Clayton.   

Abstract

A series of Trypanosoma brucei transfection vectors was constructed in which transcription of the luciferase gene was driven by the procyclic acidic repetitive protein (procyclin) promoter. The untranslated regions surrounding the luciferase gene were derived from the actin, fructose bisphosphate aldolase, or PARP loci. Trans-splicing of the resulting transcripts occurred as expected, but the site of 3' polyadenylation was upstream of the position anticipated. The nature of the 3'-untranslated region was crucial to the level of expression in bloodstream forms.

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Year:  1993        PMID： 8259136     DOI： 10.1016/0166-6851(93)90161-p

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  32 in total

1.  The length of the combined 3' untranslated region and poly(A) tail does not control rates of glyceraldehyde-3-phosphate dehydrogenase mRNA translation in three species of parasitic protists.

Authors:  B H ter Kuile; F J Sallés
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

2.  Ex vivo and in vitro identification of a consensus promoter for VSG genes expressed by metacyclic-stage trypanosomes in the tsetse fly.

Authors:  Michael L Ginger; Patricia A Blundell; Alyson M Lewis; Alison Browitt; Arthur Günzl; J David Barry
Journal:  Eukaryot Cell       Date:  2002-12

3.  A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes.

Authors:  Helena Webb; Roisin Burns; Nicola Kimblin; Louise Ellis; Mark Carrington
Journal:  RNA       Date:  2005-05-31       Impact factor: 4.942

4.  Identification of cis and trans elements involved in the cell cycle regulation of multiple genes in Crithidia fasciculata.

Authors:  R Mahmood; J C Hines; D S Ray
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

5.  Activity of a trypanosome metacyclic variant surface glycoprotein gene promoter is dependent upon life cycle stage and chromosomal context.

Authors:  S V Graham; B Wymer; J D Barry
Journal:  Mol Cell Biol       Date:  1998-03       Impact factor: 4.272

6.  DNA rearrangements associated with multiple consecutive directed antigenic switches in Trypanosoma brucei.

Authors:  M Navarro; G A Cross
Journal:  Mol Cell Biol       Date:  1996-07       Impact factor: 4.272

7.  Mechanisms of developmental regulation in Trypanosoma brucei: a polypyrimidine tract in the 3'-untranslated region of a surface protein mRNA affects RNA abundance and translation.

Authors:  H R Hotz; C Hartmann; K Huober; M Hug; C Clayton
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

8.  Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extracts.

Authors:  Joseph Milone; Jeffrey Wilusz; Vivian Bellofatto
Journal:  Nucleic Acids Res       Date:  2002-09-15       Impact factor: 16.971

9.  Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation.

Authors:  Chi-Ho Li; Henriette Irmer; Drifa Gudjonsdottir-Planck; Simone Freese; Heike Salm; Simon Haile; Antonio M Estévez; Christine Clayton
Journal:  RNA       Date:  2006-10-31       Impact factor: 4.942

10.  Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei.

Authors:  Sarah Kabani; Katelyn Fenn; Alan Ross; Al Ivens; Terry K Smith; Peter Ghazal; Keith Matthews
Journal:  BMC Genomics       Date:  2009-09-11       Impact factor: 3.969
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