Literature DB >> 8258704

Polymorphism in BoLA-DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukemia virus.

A Xu1, M J van Eijk, C Park, H A Lewin.   

Abstract

The relationship between polymorphism of the bovine lymphocyte Ag (BoLA)-DRB3 gene and resistance and susceptibility to persistent lymphocytosis (PL) caused by bovine leukemia virus (BLV) was investigated. Exon 2 of the BoLA-DRB3 gene was cloned from animals with BoLA haplotypes previously found to be associated with resistance and susceptibility to PL. Sequence analysis revealed the presence of the amino acids Glu-Arg (ER) at putative Ag binding residues 70 and 71 only in BoLA haplotypes associated with resistance to PL. This correlation was confirmed in a case control study (n = 26) using an allele-specific polymerase chain reaction for the detection of ER at residues 70-71. These results provide a molecular basis for Ir gene control of resistance and susceptibility to PL and suggest that the cellular immune response is important in preventing the in vivo spread of BLV infection.

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Year:  1993        PMID： 8258704

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  40 in total

1.  Major histocompatibility complex variation in the endangered Przewalski's horse.

Authors:  P W Hedrick; K M Parker; E L Miller; P S Miller
Journal:  Genetics       Date:  1999-08       Impact factor: 4.562

2.  Immunodominant epitopes in Babesia bovis rhoptry-associated protein 1 that elicit memory CD4(+)-T-lymphocyte responses in B. bovis-immune individuals are located in the amino-terminal domain.

Authors:  Junzo Norimine; Carlos E Suarez; Terry F McElwain; Monica Florin-Christensen; Wendy C Brown
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441

3.  Intrahaplotype and interhaplotype pairing of bovine leukocyte antigen DQA and DQB molecules generate functional DQ molecules important for priming CD4(+) T-lymphocyte responses.

Authors:  Junzo Norimine; Wendy C Brown
Journal:  Immunogenetics       Date:  2005-11-08       Impact factor: 2.846

4.  Microarray analysis of differential gene expression profiles in blood cells of naturally BLV-infected and uninfected Holstein-Friesian cows.

Authors:  P Brym; S Kamiński
Journal:  Mol Biol Rep       Date:  2016-11-03       Impact factor: 2.316

5.  Breadth of the CD4+ T cell response to Anaplasma marginale VirB9-1, VirB9-2 and VirB10 and MHC class II DR and DQ restriction elements.

Authors:  Kaitlyn Morse; Junzo Norimine; Jayne C Hope; Wendy C Brown
Journal:  Immunogenetics       Date:  2012-02-24       Impact factor: 2.846

6.  CD5 is dissociated from the B-cell receptor in B cells from bovine leukemia virus-infected, persistently lymphocytotic cattle: consequences to B-cell receptor-mediated apoptosis.

Authors:  G H Cantor; S M Pritchard; F Dequiedt; L Willems; R Kettmann; W C Davis
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

7.  Proteome analysis of sheep B lymphocytes in the course of bovine leukemia virus-induced leukemia.

Authors:  Michal Reichert
Journal:  Exp Biol Med (Maywood)       Date:  2017-04-24

8.  Extensive MHC class II DRB3 diversity in African and European cattle.

Authors:  S Mikko; L Andersson
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

9.  Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen.

Authors:  Keith T Ballingall; Anthony Luyai; G John Rowlands; Jill Sales; Anthony J Musoke; Subash P Morzaria; Declan J McKeever
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

10.  Demonstration of three DRB loci in a domestic horse family.

Authors:  D G Fraser; E Bailey
Journal:  Immunogenetics       Date:  1996       Impact factor: 2.846
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