Development, production and quality control of clinically applied antilymphocyte globulin.

Various antigens have been assessed for the ability to produce anti-human lymphocyte globulin(ALG). In our hands the most satisfactory antigen has proved to be cultured lymphoblasts. These are used to produce Behringwerke ALG(Pressimmune). A brief outline of problems in the large scale production of ALG and how these are overcome is given. The quality control checks for activity and safety are discussed.