Literature DB >> 8258399

Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy.

A J Augustin1, W Breipohl, T Böker, J Lutz, M Spitznas.   

Abstract

Lipid peroxide (LPO) levels, as determined by high-performance liquid chromatography (HPLC) and by the thiobarbituric acid (TBA) method, and myeloperoxidase (MPO) activity in vitreous of patients vitrectomized because of proliferative diabetic retinopathy were compared with LPO levels and MPO activity in vitreous of patients with no vitreoretinal proliferation. Both LPO levels and MPO activity were significantly elevated in the vitreous of patients with fibrovascular vitreoretinal proliferations secondary to diabetes. The TBA method produced higher values for LPO levels than did the HPLC method. The correlation between the two methods was 0.94. Our results suggest that both oxygen-free radicals and inflammation-related reactions can participate in the pathogenesis of diabetic retinopathy.

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Year:  1993        PMID： 8258399     DOI： 10.1007/bf00921959

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  26 in total

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Journal:  Pediatrics       Date:  1988-03       Impact factor: 7.124

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Authors:  M Weller; R Clausen; K Heimann; P Wiedemann
Journal:  Ophthalmic Res       Date:  1990       Impact factor: 2.892

Review 8.  The effect of oxidants on biomembranes and cellular metabolism.

Authors:  S K Srivastava; N H Ansari; S Liu; A Izban; B Das; G Szabo; A Bhatnagar
Journal:  Mol Cell Biochem       Date:  1989 Nov 23-Dec 19       Impact factor: 3.396

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Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

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Authors:  A Collier; M Jackson; R M Dawkes; D Bell; B F Clarke
Journal:  Diabet Med       Date:  1988-11       Impact factor: 4.359
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  14 in total

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Authors:  A J Augustin; F H Grus; F Koch; M Spitznas
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Authors:  Sandeep Saxena; Prachi Srivastava; Vinay K Khanna
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3.  Hypoxia precedes the development of experimental preretinal neovascularization.

Authors:  J T Handa; B A Berkowitz; C A Wilson; N Ando; H A Sen; G J Jaffe
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-01       Impact factor: 3.117

4.  Advanced glycation end products increase retinal vascular endothelial growth factor expression.

Authors:  M Lu; M Kuroki; S Amano; M Tolentino; K Keough; I Kim; R Bucala; A P Adamis
Journal:  J Clin Invest       Date:  1998-03-15       Impact factor: 14.808

5.  Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.

Authors:  M Kuroki; E E Voest; S Amano; L V Beerepoot; S Takashima; M Tolentino; R Y Kim; R M Rohan; K A Colby; K T Yeo; A P Adamis
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6.  Oxidative reactions in the tear fluid of patients suffering from dry eyes.

Authors:  A J Augustin; M Spitznas; N Kaviani; D Meller; F H Koch; F Grus; M J Göbbels
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1995-11       Impact factor: 3.117

Review 7.  Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Authors:  Akanksha Gupta; Sonika Bhatnagar
Journal:  OMICS       Date:  2015-12

8.  Examining the role of lipid mediators in diabetic retinopathy.

Authors:  Julia V Busik; Walter J Esselman; Gavin E Reid
Journal:  Clin Lipidol       Date:  2012-12-01

9.  Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers.

Authors:  Mohamed Al-Shabrawey; Sylvia Smith
Journal:  EPMA J       Date:  2010-03-23       Impact factor: 6.543

Review 10.  Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy.

Authors:  Daniel Gologorsky; Aristomenis Thanos; Demetrios Vavvas
Journal:  Mediators Inflamm       Date:  2012-09-17       Impact factor: 4.711
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