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Literature DB >> 8257551

Buprenorphine in opiate withdrawal: a comparison with clonidine.

Abstract

Clinical efficacy of buprenorphine in controlling withdrawal symptoms was compared against clonidine among 44 opiate dependent males. Subjective and objective withdrawal symptoms were assessed by withdrawal rating scales daily for 10 days. The subjects were randomly assigned to fixed dose schedule of either buprenorphine (0.6-1.2 mg per day, sublingually) or clonidine (0.3-0.9 mg per day, oral) for 10 days. Buprenorphine was found superior to clonidine in alleviating most of the subjective and objective opiate withdrawal symptoms. Subjective symptoms declined earlier among the subjects receiving buprenorphine. No untoward side-effects of buprenorphine were noticed.

Entities: Chemical

Mesh：

Substances：
Buprenorphine
Clonidine

Year: 1993 PMID： 8257551 DOI： 10.1016/0740-5472(93)90024-v

Source DB: PubMed Journal: J Subst Abuse Treat ISSN： 0740-5472

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Cited

19 in total

1. A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network.

Authors: Walter Ling; Leslie Amass; Steve Shoptaw; Jeffrey J Annon; Maureen Hillhouse; Dean Babcock; Greg Brigham; Judy Harrer; Malcolm Reid; Joan Muir; Betty Buchan; Debbie Orr; George Woody; Jonathan Krejci; Douglas Ziedonis
Journal: Addiction Date: 2005-08 Impact factor: 6.526

2. Comparative trial to study the effectiveness of clonidine hydrochloride and buprenorphine-naloxone in opioid withdrawal - a hospital based study.

Authors: Syed Sajad Hussain; Samina Farhat; Yasir Hassan Rather; Zaffar Abbas
Journal: J Clin Diagn Res Date: 2015-01-01

10. The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) Prisons Project Study: protocol for a randomised controlled trial comparing methadone and buprenorphine for opiate detoxification.

Authors: Laura Sheard; Nat M J Wright; Clive E Adams; Nicole Bound; Bruno Rushforth; Roger Hart; Charlotte N E Tompkins
Journal: Trials Date: 2009-07-14 Impact factor: 2.279

Buprenorphine in opiate withdrawal: a comparison with clonidine.

1. A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network.

2. Comparative trial to study the effectiveness of clonidine hydrochloride and buprenorphine-naloxone in opioid withdrawal - a hospital based study.

Review 3. Buprenorphine for managing opioid withdrawal.

4. Buprenorphine abuse in India : an update.

Review 5. Opioid dependence treatment: options in pharmacotherapy.

Review 6. Treatment of heroin (diamorphine) addiction: current approaches and future prospects.

7. Comparison of the efficacy of buprenorphine and clonidine in detoxification of opioid-dependents.

8. Heroin detoxification with buprenorphine on an inpatient psychiatric unit.

9. Opioid detoxification via single 7-day application of a buprenorphine transdermal patch: an open-label evaluation.

10. The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) Prisons Project Study: protocol for a randomised controlled trial comparing methadone and buprenorphine for opiate detoxification.