Literature DB >> 8257440

Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica.

A Mehlert1, L Varon, I Silman, S W Homans, M A Ferguson.   

Abstract

The structure of the glycan moiety of the glycosyl-phosphatidylinositol (GPI) membrane anchor from Torpedo californica (electric fish) electric-organ acetylcholinesterase was solved using n.m.r., methylation analysis and chemical and enzymic micro-sequencing. Two structures were found to be present: Glc alpha 1-2Man alpha 1-2Man alpha 1-6Man alpha 1-4GlcN alpha 1-6myo-inositol and Glc alpha 1-2Man alpha 1-2Man alpha 1-6(GalNAc beta 1-4)Man alpha 1-4GlcN alpha 1-6myo-inositol. The presence of glucose in this GPI anchor structure is a novel feature. The anchor was also shown to contain 2.3 residues of ethanolamine per molecule.

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Year:  1993        PMID： 8257440      PMCID： PMC1137719          DOI： 10.1042/bj2960473

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  31 in total

Review 1.  Colworth Medal Lecture. Glycosyl-phosphatidylinositol membrane anchors: the tale of a tail.

Authors:  M A Ferguson
Journal:  Biochem Soc Trans       Date:  1992-05       Impact factor: 5.407

2.  Phosphorus assay in column chromatography.

Authors:  G R BARTLETT
Journal:  J Biol Chem       Date:  1959-03       Impact factor: 5.157

Review 3.  The glycosyl-phosphatidylinositol anchor of membrane proteins.

Authors:  M G Low
Journal:  Biochim Biophys Acta       Date:  1989-12-06

4.  Divergence in primary structure between the molecular forms of acetylcholinesterase.

Authors:  G Gibney; K MacPhee-Quigley; B Thompson; T Vedvick; M G Low; S S Taylor; P Taylor
Journal:  J Biol Chem       Date:  1988-01-25       Impact factor: 5.157

Review 5.  The structure and biosynthesis of glycosyl phosphatidylinositol protein anchors.

Authors:  P T Englund
Journal:  Annu Rev Biochem       Date:  1993       Impact factor: 23.643

Review 6.  Polarized sorting of GPI-linked proteins in epithelia and membrane microdomains.

Authors:  M P Lisanti; E Rodríguez-Boulan
Journal:  Cell Biol Int Rep       Date:  1991-11

7.  G2-acetylcholinesterase is presynaptically localized in Torpedo electric organ.

Authors:  J Eichler; I Silman; L Anglister
Journal:  J Neurocytol       Date:  1992-10

8.  Glycan components in the glycoinositol phospholipid anchor of human erythrocyte acetylcholinesterase. Novel fragments produced by trifluoroacetic acid.

Authors:  M A Deeg; D R Humphrey; S H Yang; T R Ferguson; V N Reinhold; T L Rosenberry
Journal:  J Biol Chem       Date:  1992-09-15       Impact factor: 5.157

9.  Interactions between GPI-anchored proteins and membrane lipids.

Authors:  D A Brown
Journal:  Trends Cell Biol       Date:  1992-11       Impact factor: 20.808

10.  Structural studies on the glycosylphosphatidylinositol membrane anchor of Trypanosoma cruzi 1G7-antigen. The structure of the glycan core.

Authors:  M L Güther; M L de Almeida; N Yoshida; M A Ferguson
Journal:  J Biol Chem       Date:  1992-04-05       Impact factor: 5.157
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  5 in total

1.  Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes.

Authors:  I Shin; I Silman; L M Weiner
Journal:  Protein Sci       Date:  1996-01       Impact factor: 6.725

2.  Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin.

Authors:  R Tarrab-Hazdai; L Toker; I Silman; R Arnon
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

3.  Analysis of glycosylphosphatidylinositol membrane anchors by electrospray ionization-mass spectrometry and collision induced dissociation.

Authors:  C A Redman; B N Green; J E Thomas-Oates; V N Reinhold; M A Ferguson
Journal:  Glycoconj J       Date:  1994-06       Impact factor: 2.916

4.  Glycoinositol phospholipid anchor and protein C-terminus of bovine erythrocyte acetylcholinesterase: analysis by mass spectrometry and by protein and DNA sequencing.

Authors:  R Haas; B C Jackson; B Reinhold; J D Foster; T L Rosenberry
Journal:  Biochem J       Date:  1996-03-15       Impact factor: 3.857

5.  The glycoinositol-phospholipids of Phytomonas.

Authors:  C A Redman; P Schneider; A Mehlert; M A Ferguson
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857
  5 in total

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