Literature DB >> 8257413

The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme protein.

A L Jones1, R C Roberts, M W Coughtrie.   

Abstract

We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.

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Year:  1993        PMID： 8257413      PMCID： PMC1137690          DOI： 10.1042/bj2960287

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  Rat brain phenolsulfotransferase: partial purification and some properties.

Authors:  A Foldes; J L Meek
Journal:  Biochim Biophys Acta       Date:  1973-12-19

2.  Platelet phenol sulfotransferase activity: correlation with sulfate conjugation of acetaminophen.

Authors:  C Reiter; R Weinshilboum
Journal:  Clin Pharmacol Ther       Date:  1982-11       Impact factor: 6.875

3.  Multiple forms of phenolsulphotransferase in human tissues: selective inhibition by dichloronitrophenol.

Authors:  G Rein; V Glover; M Sandler
Journal:  Biochem Pharmacol       Date:  1982-05-15       Impact factor: 5.858

4.  Human platelet phenol sulfotransferase: partial purification and detection of two forms of the enzyme.

Authors:  P R Butler; R J Anderson; D L Venton
Journal:  J Neurochem       Date:  1983-09       Impact factor: 5.372

5.  Human platelet phenolsulphotransferase M and P: substrate specificities and correlation with in vivo sulphoconjugation of paracetamol and salicylamide.

Authors:  S M Bonham Carter; G Rein; V Glover; M Sandler; J Caldwell
Journal:  Br J Clin Pharmacol       Date:  1983-03       Impact factor: 4.335

6.  Human phenol sulfotransferase: correlation of brain and platelet activities.

Authors:  W F Young; E R Laws; F W Sharbrough; R M Weinshilboum
Journal:  J Neurochem       Date:  1985-04       Impact factor: 5.372

7.  Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity.

Authors:  N R Campbell; R S Sundaram; P G Werness; J Van Loon; R M Weinshilboum
Journal:  Clin Pharmacol Ther       Date:  1985-03       Impact factor: 6.875

8.  Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation.

Authors:  C Reiter; G Mwaluko; J Dunnette; J Van Loon; R Weinshilboum
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-09       Impact factor: 3.000

9.  Human platelet phenol sulphotransferase: assay procedure, substrate and tissue correlations.

Authors:  R J Anderson; R M Weinshilboum; S F Phillips; D D Broughton
Journal:  Clin Chim Acta       Date:  1981-03-05       Impact factor: 3.786
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  9 in total

1.  Reduced platelet phenolsulphotransferase activity towards dopamine and 5-hydroxytryptamine in migraine.

Authors:  A L Jones; R C Roberts; D W Colvin; G L Rubin; M W Coughtrie
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

Review 2.  Molecular basis of polymorphic drug metabolism.

Authors:  A K Daly
Journal:  J Mol Med (Berl)       Date:  1995-11       Impact factor: 4.599

Review 3.  The pharmacokinetics of levosalbutamol: what are the clinical implications?

Authors:  D W Boulton; J P Fawcett
Journal:  Clin Pharmacokinet       Date:  2001-01       Impact factor: 6.447

4.  Functional genetic variants in the 3'-untranslated region of sulfotransferase isoform 1A1 (SULT1A1) and their effect on enzymatic activity.

Authors:  Xinfeng Yu; Ishwori B Dhakal; Marjorie Beggs; Vineetha Koroth Edavana; Suzanne Williams; Xuemei Zhang; Kelly Mercer; Baitang Ning; Nicholas P Lang; Fred F Kadlubar; Susan Kadlubar
Journal:  Toxicol Sci       Date:  2010-09-29       Impact factor: 4.849

5.  Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations.

Authors:  M W Coughtrie; R A Gilissen; B Shek; R C Strange; A A Fryer; P W Jones; D E Bamber
Journal:  Biochem J       Date:  1999-01-01       Impact factor: 3.857

Review 6.  Pharmacogenetics of soluble sulfotransferases (SULTs).

Authors:  Hansruedi Glatt; Walter Meinl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-11-05       Impact factor: 3.000

7.  Sulfur metabolism in ulcerative colitis: investigation of detoxification enzymes in peripheral blood.

Authors:  M C Pitcher; E R Beatty; R M Harris; R H Waring; J H Cummings
Journal:  Dig Dis Sci       Date:  1998-09       Impact factor: 3.199

8.  Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2).

Authors:  A M O'Halloran; C C Patterson; P Horan; A Maree; R Curtin; A Stanton; P P McKeown; D C Shields
Journal:  J Thromb Thrombolysis       Date:  2008-02-08       Impact factor: 2.300

9.  Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer.

Authors:  Rakhshan Ihsan; Pradeep Singh Chauhan; Ashwani Kumar Mishra; Dhirendra Singh Yadav; Mishi Kaushal; Jagannath Dev Sharma; Eric Zomawia; Yogesh Verma; Sujala Kapur; Sunita Saxena
Journal:  PLoS One       Date:  2011-12-19       Impact factor: 3.240
  9 in total

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