| Literature DB >> 8255079 |
S Nagai1, M Yamauchi, T Satta, Y Kodera, K Kondou, S Akiyaya, K Ito, H Takagi.
Abstract
A water-soluble and stable camptothecin derivative, CPT-11, was found to possess a strong antitumor activity against various murine tumors. In the present study, CPT-11 was tested against ten human gastrointestinal cancer xenograft lines carried by nude mice. CPT-11 was very effective against nine xenograft lines, with the exception of one xenograft. On the other hand, VP-16 was ineffective against all these xenograft lines. Therefore, CPT-11 is expected to be clinically more effective against gastrointestinal cancer than the topo II targeting agent.Entities:
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Year: 1993 PMID： 8255079 DOI： 10.1002/jso.2930540404
Source DB: PubMed Journal: J Surg Oncol ISSN： 0022-4790 Impact factor: 3.454