Literature DB >> 8254761

Glycoprotein gB (gII) of pseudorabies virus can functionally substitute for glycoprotein gB in herpes simplex virus type 1.

T C Mettenleiter1, P G Spear.   

Abstract

Glycoproteins homologous to gB of herpes simplex virus (HSV) constitute the most highly conserved family of herpesvirus glycoproteins. All gB homologs analyzed so far have been shown to play essential roles in penetration and direct viral cell-to-cell spread. In studies aimed at assessing whether the high sequence homology is also indicative of functional homology, we analyzed the ability of the gB-homologous glycoprotein (former designation gII) of pseudorabies virus (PrV) to complement a gB- HSV type 1 (HSV-1) mutant and vice versa. The results show that a PrV gB-expressing cell line phenotypically complemented the lethal defect in gB- HSV-1 whereas reciprocal complementation of a gB- PrV mutant by HSV-1 gB was not observed.

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Year:  1994        PMID： 8254761      PMCID： PMC236311     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

1.  Oligomer formation of the gB glycoprotein of herpes simplex virus type 1.

Authors:  S L Highlander; W F Goins; S Person; T C Holland; M Levine; J C Glorioso
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

2.  Cleavage of the bovine herpesvirus glycoprotein B is not essential for its function.

Authors:  E L Blewett; V Misra
Journal:  J Gen Virol       Date:  1991-09       Impact factor: 3.891

3.  Limited proteolysis of herpes simplex virus glycoproteins that occurs during their extraction from vero cells.

Authors:  K M Zezulak; P G Spear
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

4.  Construction of herpes simplex viruses that are pseudodiploid for the glycoprotein B gene: a strategy for studying the function of an essential herpesvirus gene.

Authors:  V Misra; E L Blewett
Journal:  J Gen Virol       Date:  1991-02       Impact factor: 3.891

5.  Pseudorabies virus glycoproteins gII and gp50 are essential for virus penetration.

Authors:  I Rauh; T C Mettenleiter
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

6.  Domains of herpes simplex virus I glycoprotein B that function in virus penetration, cell-to-cell spread, and cell fusion.

Authors:  D Navarro; P Paz; L Pereira
Journal:  Virology       Date:  1992-01       Impact factor: 3.616

7.  Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion.

Authors:  B Peeters; N de Wind; M Hooisma; F Wagenaar; A Gielkens; R Moormann
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

8.  Stable rescue of a glycoprotein gII deletion mutant of pseudorabies virus by glycoprotein gI of bovine herpesvirus 1.

Authors:  A Kopp; T C Mettenleiter
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

9.  Isolation, characterization, and physical mapping of a pseudorabies virus mutant containing antigenically altered gp50.

Authors:  M W Wathen; L M Wathen
Journal:  J Virol       Date:  1984-07       Impact factor: 5.103

10.  A glycoprotein gX-beta-galactosidase fusion gene as insertional marker for rapid identification of pseudorabies virus mutants.

Authors:  T C Mettenleiter; I Rauh
Journal:  J Virol Methods       Date:  1990-10       Impact factor: 2.014
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  21 in total

1.  Pseudorabies virus expressing bovine herpesvirus 1 glycoprotein B exhibits altered neurotropism and increased neurovirulence.

Authors:  V Gerdts; J Beyer; B Lomniczi; T C Mettenleiter
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virion localization of glycoprotein H.

Authors:  B G Klupp; W Fuchs; E Weiland; T C Mettenleiter
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

3.  Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion.

Authors:  Doina Atanasiu; Wan Ting Saw; Roselyn J Eisenberg; Gary H Cohen
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

4.  Two viral kinases are required for sustained long distance axon transport of a neuroinvasive herpesvirus.

Authors:  Kelly E Coller; Gregory A Smith
Journal:  Traffic       Date:  2008-06-28       Impact factor: 6.215

5.  The receptor-binding domain of pseudorabies virus glycoprotein gC is composed of multiple discrete units that are functionally redundant.

Authors:  S J Flynn; P Ryan
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

6.  The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein.

Authors:  K M Koslowski; P R Shaver; X Y Wang; D J Tenney; N E Pederson
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

7.  Identification and characterization of a novel structural glycoprotein in pseudorabies virus, gL.

Authors:  B G Klupp; J Baumeister; A Karger; N Visser; T C Mettenleiter
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

8.  Proteolytic cleavage of bovine herpesvirus 1 (BHV-1) glycoprotein gB is not necessary for its function in BHV-1 or pseudorabies virus.

Authors:  A Kopp; E Blewett; V Misra; T C Mettenleiter
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

9.  Partial functional complementation of a pseudorabies virus UL25 deletion mutant by herpes simplex virus type 1 pUL25 indicates overlapping functions of alphaherpesvirus pUL25 proteins.

Authors:  Jana Kuhn; Tobias Leege; Barbara G Klupp; Harald Granzow; Walter Fuchs; Thomas C Mettenleiter
Journal:  J Virol       Date:  2008-04-09       Impact factor: 5.103

10.  Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.

Authors:  R Tal-Singer; C Peng; M Ponce De Leon; W R Abrams; B W Banfield; F Tufaro; G H Cohen; R J Eisenberg
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103
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