Post recognition ion dependent events in mitogen induced lymphocyte proliferation and in cytotoxic effector cell responses.

This review discusses the increased permeability and enhanced uptake transport of monovalent and divalent cations following mitogen-induced lymphocyte proliferation. The observed Ca2+ uptake is discussed in terms of gated Ca2+ channels. The importance of divalent cations, particularly Ca2+, is discussed in terms of triggering of cytotoxic effector cell responses for three model systems (antibody dependent cytotoxicity, mitogen-induced cytotoxicity and cell mediated cytotoxicity); (85).