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Literature DB >> 825383

Influence of endogenous pyrogen on the cerebral prostaglandin-synthetase system.

Abstract

The biotransformation of arachidonic acid to prostaglandins in vitro is specifically augmented by endogenous pyrogen to a degree depending on the concentration applied, providing that the microsomal fraction of the cerebral cortex is used as prostaglandin-synthetase system. This effect is inhibited by non-steroidal anti-inflammatory agents. These findings are compatible with the hypothesis that prostaglandins might act as mediators of the febrile reaction induced by endogenous pyrogen.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 825383 DOI： 10.1007/BF01937428

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

17 in total

1. Chemical properties of leucocytic pyrogen. I. Partial purification of rabbit leucocytic pyrogen.

Authors: G W GANDER; F GOODALE
Journal: Exp Mol Pathol Date: 1962-10 Impact factor: 3.362

2. Identification of prostaglandin E by radioimmunoassay in cerebrospinal fluid during endotoxin fever.

Authors: W K Philipp-Dormston; R Siegert
Journal: Naturwissenschaften Date: 1974-03

3. Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase.

Authors: C Takeguchi; E Kono; C J Sih
Journal: Biochemistry Date: 1971-06-08 Impact factor: 3.162

4. Drugs which inhibit prostaglandin biosynthesis.

Authors: R J Flower
Journal: Pharmacol Rev Date: 1974-03 Impact factor: 25.468

5. Effect of pyrogen and antipyretics on prostaglandin acitvity in cisternal c.s.f. of unanaesthetized cats.

Authors: W Feldberg; K P Gupta; A S Milton; S Wendlandt
Journal: J Physiol Date: 1973-10 Impact factor: 5.182

6. Fever produced by prostaglandin E1.

Authors: W Feldberg; P N Saxena
Journal: J Physiol Date: 1971-09 Impact factor: 5.182

7. Pyrogen fever and prostaglandin-like activity in cerebrospinal fluid.

Authors: W Feldberg; K P Gupta
Journal: J Physiol Date: 1973-01 Impact factor: 5.182

8. Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits.

Authors: A S Milton; S Wendlandt
Journal: J Physiol Date: 1971-10 Impact factor: 5.182

9. Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen.

Authors: D L BORNSTEIN; C BREDENBERG; W B WOOD
Journal: J Exp Med Date: 1963-03-01 Impact factor: 14.307

10. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.

Authors: I L BENNETT; P B BEESON
Journal: J Exp Med Date: 1953-11 Impact factor: 14.307

6 in total

1. Intraventricular injections of drugs which inhibit phospholipase A2 suppress fever in rabbits.

Authors: W I Cranston; R F Hellon; D Mitchell; Y Townsend
Journal: J Physiol Date: 1983-06 Impact factor: 5.182

2. Blockade of prostaglandin E1 hyperthermia by sodium salicylate given into the ventral septal area of the rat brain.

Authors: S J Alexander; K E Cooper; W L Veale
Journal: J Physiol Date: 1987-03 Impact factor: 5.182

3. Nucleus tractus solitarii lesions alter the metabolic and hyperthermic response to central prostaglandin E1 in the rat.

Authors: D M Fyda; K E Cooper; W L Veale
Journal: J Physiol Date: 1991-10 Impact factor: 5.182