Eosinophilic perifolliculitis: a variant of autoimmune oophoritis?

We report two middle-aged women with ovarian perifolliculitis consisting mostly of eosinophils. Both had enlarged cystic ovaries that on histological examination showed a perifollicular inflammatory infiltrate consisting of lymphocytes, plasma cells, and large numbers of eosinophils. The inflammatory infiltrate increased in intensity with follicular maturation and appeared to be destroying the theca interna. Circulating antiovarian, antiadrenal, and antithyroid antibodies were negative in both cases. We also compare these cases to lymphoplasmacytic autoimmune oophoritis.