BACKGROUND: In patients with asthma, gastroesophageal reflux (GER) has been shown to be a common finding, and a number of investigators have suggested that reflux may have a deleterious effect in asthma, either as a result of recurrent (micro)aspiration or by some form of a reflex mechanism. AIM OF THE STUDY: To measure changes in lung function in response to intraesophageal acid perfusion in asthmatics with GER. METHODS: In 12 patients with bronchial asthma and complaints suggesting GER with increased reflux scores during 24-h intraesophageal pH monitoring, impedance measurements of the respiratory system using the technique of forced oscillations and spirometry were performed after intraesophageal acidification. RESULTS: No statistically significant changes in FEV1 or in respiratory impedance were demonstrated after intraesophageal acid provocation. CONCLUSION: No direct effect of intraesophageal acidification on bronchomotor tone was demonstrated in asthmatics with GER.
BACKGROUND: In patients with asthma, gastroesophageal reflux (GER) has been shown to be a common finding, and a number of investigators have suggested that reflux may have a deleterious effect in asthma, either as a result of recurrent (micro)aspiration or by some form of a reflex mechanism. AIM OF THE STUDY: To measure changes in lung function in response to intraesophageal acid perfusion in asthmatics with GER. METHODS: In 12 patients with bronchial asthma and complaints suggesting GER with increased reflux scores during 24-h intraesophageal pH monitoring, impedance measurements of the respiratory system using the technique of forced oscillations and spirometry were performed after intraesophageal acidification. RESULTS: No statistically significant changes in FEV1 or in respiratory impedance were demonstrated after intraesophageal acid provocation. CONCLUSION: No direct effect of intraesophageal acidification on bronchomotor tone was demonstrated in asthmatics with GER.
Authors: Ana Carla S Araujo; Lílian Rose O Aprile; Roberto O Dantas; João Terra-Filho; Elcio O Vianna Journal: Lung Date: 2008-02-23 Impact factor: 2.584
Authors: D Lakmali Amarasiri; Arunasalam Pathmeswaran; H Janaka de Silva; Channa D Ranasinha Journal: BMC Pulm Med Date: 2013-06-02 Impact factor: 3.317