Literature DB >> 8252640

Molecular cloning of the PEL1 gene of Saccharomyces cerevisiae that is essential for the viability of petite mutants.

M Janitor1, J Subík.   

Abstract

The PEL1 gene of Saccharomyces cerevisiae is essential for the cell viability of mitochondrial petite mutants, for the ability to utilize glycerol and ethanol on synthetic medium, and for cell growth at higher temperatures. By tetrad analysis the gene was assigned to chromosome III, centromere proximal of LEU2. The PEL1 gene has been isolated and cloned by the complementation of a pel1 mutation. The molecular analysis of the chromosomal insert carrying PEL1 revealed that this gene corresponds to the YCL4W open reading frame on the complete DNA sequence of chromosome III. The putative Pel1 protein is characterized by a low molecular weight of approximately 17 kDa, a low codon adaptation index, and a high leucine content.

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Year:  1993        PMID： 8252640     DOI： 10.1007/bf00336781

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  23 in total

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2.  A novel viral oncogene with structural similarity to phospholipase C.

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Journal:  FEBS Lett       Date:  1974-06-15       Impact factor: 4.124

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5.  The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.

Authors:  P M Sharp; W H Li
Journal:  Nucleic Acids Res       Date:  1987-02-11       Impact factor: 16.971

6.  Transformation of nuclear respiratory deficient mutants of yeast.

Authors:  C L Dieckmann; A Tzagoloff
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

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Authors:  M D Rose; P Novick; J H Thomas; D Botstein; G R Fink
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Authors:  K A Nasmyth; S I Reed
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Authors:  L Kovác; J Kolarov; J Subík
Journal:  Mol Cell Biochem       Date:  1977-02-04       Impact factor: 3.396

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Authors:  M Ciriacy
Journal:  Mol Gen Genet       Date:  1976-06-15
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  21 in total

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8.  Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling.

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10.  Cardiolipin mediates cross-talk between mitochondria and the vacuole.

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