BACKGROUND: Reported experiences regarding the prognostic significance of DNA content in colorectal carcinoma have been a matter of controversy. METHODS: DNA analysis with image cytometry was performed in 137 patients with colorectal cancer. Only patients who had resection without tumor residual and who did not die postoperatively as a consequence of the operation were entered in the study. At the time of DNA analysis, neither the histomorphologic data nor the relapse-free survival time of the patients were known. RESULTS: In this investigation the DNA content of tumor cells had no univariate or multivariate influence on the relapse-free survival time. The prognosis was dependent on the tumor localization, depth of tumor infiltration, lymph node metastasis, and grade. CONCLUSIONS: DNA content provides no additional prognostic information in colorectal carcinoma.
BACKGROUND: Reported experiences regarding the prognostic significance of DNA content in colorectal carcinoma have been a matter of controversy. METHODS: DNA analysis with image cytometry was performed in 137 patients with colorectal cancer. Only patients who had resection without tumor residual and who did not die postoperatively as a consequence of the operation were entered in the study. At the time of DNA analysis, neither the histomorphologic data nor the relapse-free survival time of the patients were known. RESULTS: In this investigation the DNA content of tumor cells had no univariate or multivariate influence on the relapse-free survival time. The prognosis was dependent on the tumor localization, depth of tumor infiltration, lymph node metastasis, and grade. CONCLUSIONS: DNA content provides no additional prognostic information in colorectal carcinoma.
Authors: Timo Gemoll; Uwe J Roblick; Silke Szymczak; Till Braunschweig; Susanne Becker; Bernd-Wolfgang Igl; Hans-Peter Bruch; Andreas Ziegler; Ulf Hellman; Michael J Difilippantonio; Thomas Ried; Hans Jörnvall; Gert Auer; Jens K Habermann Journal: Cell Mol Life Sci Date: 2011-02-03 Impact factor: 9.261
Authors: U Kressner; G Lindmark; B Tomasini-Johansson; R Bergström; B Gerdin; L Påhlman; B Glimelius Journal: Br J Cancer Date: 1997 Impact factor: 7.640