| Literature DB >> 8252040 |
M Emi1, T Katagiri, Y Harada, H Saito, J Inazawa, I Ito, F Kasumi, Y Nakamura.
Abstract
From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC.Entities:
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Year: 1993 PMID： 8252040 DOI： 10.1038/ng1093-151
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330