Literature DB >> 8251396

Prognostic value of a novel circulating serum 90K antigen in HIV-infected haemophilia patients.

G Longo1, C Natoli, D Rafanelli, N Tinari, M Morfini, P Rossi-Ferrini, N D'Ostilio, S Iacobelli.   

Abstract

We evaluated the prognostic role of a novel tumour-associated antigen, termed 90K, in a cohort of HIV+ asymptomatic haemophilia patients with known duration of seropositivity and median follow-up of about 7 years. The circulating levels of 90K are higher in HIV+ asymptomatic patients than HIV- controls. The antigen levels remain quite stable over time in non-progressing patients, while they steadily rise in patients evolving to ARC/AIDS. Baseline high 90K levels are predictive of faster progression to ARC/AIDS and shorter survival. We conclude that an elevated 90K serum level is a predictor of poor prognosis in HIV+ asymptomatic haemophiliacs.

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Year:  1993        PMID： 8251396     DOI： 10.1111/j.1365-2141.1993.tb08674.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  8 in total

1.  Elevated plasma levels of 90K (Mac-2 BP) immunostimulatory glycoprotein in HIV-1-infected children.

Authors:  B Gröschel; J J Braner; M Funk; R Linde; H W Doerr; J Cinatl; S Iacobelli
Journal:  J Clin Immunol       Date:  2000-03       Impact factor: 8.317

Review 2.  Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature.

Authors:  Jean-François Gélinas; Deborah R Gill; Stephen C Hyde
Journal:  Microbiol Mol Biol Rev       Date:  2018-01-10       Impact factor: 11.056

3.  Differential effect on TCR:CD3 stimulation of a 90-kD glycoprotein (gp90/Mac-2BP), a member of the scavenger receptor cysteine-rich domain protein family.

Authors:  B Silvestri; F Calderazzo; V Coppola; A Rosato; S Iacobelli; C Natoli; A Ullrich; I Sures; M Azam; C Brakebush; L Chieco-Bianchi; A Amadori
Journal:  Clin Exp Immunol       Date:  1998-09       Impact factor: 4.330

4.  Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

Authors:  T Sasaki; C Brakebusch; J Engel; R Timpl
Journal:  EMBO J       Date:  1998-03-16       Impact factor: 11.598

Review 5.  Cellular Antiviral Factors that Target Particle Infectivity of HIV-1.

Authors:  Christine Goffinet
Journal:  Curr HIV Res       Date:  2016       Impact factor: 1.581

6.  90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1.

Authors:  Veronika Lodermeyer; Kristina Suhr; Nicola Schrott; Christian Kolbe; Christina M Stürzel; Daniela Krnavek; Jan Münch; Christian Dietz; Tanja Waldmann; Frank Kirchhoff; Christine Goffinet
Journal:  Retrovirology       Date:  2013-10-24       Impact factor: 4.602

7.  M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner.

Authors:  Qin Wang; Xiaolin Zhang; Yuling Han; Xinlu Wang; Guangxia Gao
Journal:  Sci Rep       Date:  2016-09-08       Impact factor: 4.379

Review 8.  Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z.

Authors:  Salvatore Sciacchitano; Luca Lavra; Alessandra Morgante; Alessandra Ulivieri; Fiorenza Magi; Gian Paolo De Francesco; Carlo Bellotti; Leila B Salehi; Alberto Ricci
Journal:  Int J Mol Sci       Date:  2018-01-26       Impact factor: 5.923
  8 in total

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