Literature DB >> 8250921

Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X.

A Pizzuti1, M Gennarelli, G Novelli, A Colosimo, S Lo Cicero, C T Caskey, B Dallapiccola.   

Abstract

We report here the isolation and characterization of a novel human elongation factor-1 beta (EF-1 beta) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1 beta cDNAs. We also assigned the loci for three other EF-1 beta isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1 beta loci demonstrates the genetic heterogeneity of human EF-1 beta peptides.

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Year:  1993        PMID： 8250921     DOI： 10.1006/bbrc.1993.2454

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Refinement of the spinal muscular atrophy locus by genetic and physical mapping.

Authors:  C H Wang; P W Kleyn; E Vitale; B M Ross; L Lien; J Xu; T A Carter; L M Brzustowicz; S Obici; S Selig
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

2.  Mapping the human translation elongation factor eEF1H complex using the yeast two-hybrid system.

Authors:  Francisco Mansilla; Irene Friis; Mandana Jadidi; Karen M Nielsen; Brian F C Clark; Charlotte R Knudsen
Journal:  Biochem J       Date:  2002-08-01       Impact factor: 3.857

3.  The elongation factor 1 A-2 isoform from rabbit: cloning of the cDNA and characterization of the protein.

Authors:  S Kahns; A Lund; P Kristensen; C R Knudsen; B F Clark; J Cavallius; W C Merrick
Journal:  Nucleic Acids Res       Date:  1998-04-15       Impact factor: 16.971

4.  The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene.

Authors:  D M Chambers; J Peters; C M Abbott
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

Review 5.  The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases.

Authors:  Luigi Cristiano
Journal:  Genes Dis       Date:  2021-04-16

6.  Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein.

Authors:  Francisco Mansilla; Carlota A G Dominguez; James E Yeadon; Thomas J Corydon; Steven J Burden; Charlotte R Knudsen
Journal:  J Cell Biochem       Date:  2008-10-15       Impact factor: 4.429

7.  Characterisation of translation elongation factor eEF1B subunit expression in mammalian cells and tissues and co-localisation with eEF1A2.

Authors:  Yuan Cao; Miriam Portela; Justyna Janikiewicz; Jennifer Doig; Catherine M Abbott
Journal:  PLoS One       Date:  2014-12-01       Impact factor: 3.240

8.  Identification of modules of hepatic encephalopathy based on protein-protein network and gene expression data.

Authors:  Hao Wu; Miao Liu; Jiajun Zhuang
Journal:  Exp Ther Med       Date:  2018-03-06       Impact factor: 2.447

9.  Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.

Authors:  Dinesh C Soares; Paul N Barlow; Helen J Newbery; David J Porteous; Catherine M Abbott
Journal:  PLoS One       Date:  2009-07-28       Impact factor: 3.240

10.  Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids.

Authors:  Woojung Shin; Alexander Wu; Soyoun Min; Yong Cheol Shin; R Y Declan Fleming; S Gail Eckhardt; Hyun Jung Kim
Journal:  iScience       Date:  2020-07-16
  10 in total

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