[Reinfarction after thrombolytic therapy. Results obtained with readministration of thrombolytic agent in 3 patients].

From 1985 to 1990, 120 patients within 6h after the onset of acute myocardial infarction were submitted to thrombolytic treatment. In 4 patients, there were clinical and electrocardiographic (ECG) changes of reinfarction. Three of them were undergone to a second thrombolytic therapy with streptokinase (SK). Two had infarction of the inferior wall, and one on the anterior wall. The patients were managed with the same SK dosage as in the first episode and the same protocol of infusion. All 3 patients, after new SK infusion showed evidence of myocardial reperfusion with relief of pain and improvement of the ECG. One patient, 24h after retreatment, had another reinfarction treated with emergency angioplasty of the right coronary artery, which was totally occluded. One patient (case n. 2), presented haematoma of right arm after punction of the subclavian vein and the other two patients did not show any serious intecorrence related to the new thrombolytic treatment. All of them were found alive over one year of follow-up.