[The role of second messengers in the modulation of the plasticity of the cholinoreceptors of the snail RPa3 neuron by the opiate kappa agonist bremazocine].

In the paper was shown the participation of some second messengers in intracellular molecular mechanism of a decrease of RPa3 neuron cholinoreceptor plasticity by opiate kappa-agonist bremazocine during rhythmical acetylcholine application. This mechanism includes 1) inhibition of inositol-1,4,5-trisphosphate-dependent mobilization of deposited Ca2+ activating intracellular receptor calmodulin and 2) inhibition of the synthesis of the acyclic eicosanoids. It is possible to assume a specificity of this mechanism, so far as is not revealed the role of the second messengers under study in bremazocine inhibitors of RPa3 neuron somatic cholinoreceptors under the conditions of non-rhythmical acetylcholine application.