Literature DB >> 8249041

Nicotine, cotinine, and trans-3-hydroxycotinine levels in seminal plasma of smokers: effects on sperm parameters.

R Pacifici1, I Altieri, L Gandini, A Lenzi, S Pichini, M Rosa, P Zuccaro, F Dondero.   

Abstract

Sperm samples from 44 cigarette smokers and 50 nonsmokers attending an infertility clinic were examined by high-performance liquid chromatography (HPLC) assay and HPLC-mass spectrometry for the presence of nicotine (NIC), cotinine (COT), and trans-3'-hydroxycotinine (THOC) in seminal plasma. Smokers were found to have levels of COT and THOC in seminal plasma that were similar to those found in serum. The level of NIC was significantly increased in seminal plasma compared to serum. Total motility of spermatozoa was significantly and negatively correlated to COT and THOC levels in seminal plasma. Forward motility of spermatozoa was correlated only with cotinine semen levels. On the basis of these results, we suggest that the presence of tobacco smoke constituents in seminal plasma could provide a warning of the adverse effects of cigarette smoke on the physiology of reproduction.

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Year:  1993        PMID： 8249041     DOI： 10.1097/00007691-199310000-00002

Source DB:  PubMed          Journal:  Ther Drug Monit        ISSN： 0163-4356            Impact factor:   3.681


  15 in total

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Authors:  Shu Li; DanDan Lu; Yaling Zhang; Yi Zhang
Journal:  J Assist Reprod Genet       Date:  2013-11-13       Impact factor: 3.412

2.  Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers.

Authors:  Ping-Chi Hsu; I-Yueh Chen; Chih-Hong Pan; Kuen-Yuh Wu; Min-Hsiung Pan; Jenq-Renn Chen; Cheng-Jung Chen; Guo-Ping Chang-Chien; Chang-Hung Hsu; Chiu-Shong Liu; Ming-Tsang Wu
Journal:  Int Arch Occup Environ Health       Date:  2005-12-15       Impact factor: 3.015

Review 3.  Drug monitoring in nonconventional biological fluids and matrices.

Authors:  S Pichini; I Altieri; P Zuccaro; R Pacifici
Journal:  Clin Pharmacokinet       Date:  1996-03       Impact factor: 6.447

Review 4.  Drugs in semen.

Authors:  S Pichini; P Zuccaro; R Pacifici
Journal:  Clin Pharmacokinet       Date:  1994-05       Impact factor: 6.447

Review 5.  Paternal smoking and germ cell death: A mechanistic link to the effects of cigarette smoke on spermatogenesis and possible long-term sequelae in offspring.

Authors:  Prabagaran Esakky; Kelle H Moley
Journal:  Mol Cell Endocrinol       Date:  2016-07-14       Impact factor: 4.102

Review 6.  The contribution of bacteriophages to the aetiology and treatment of the bacterial vaginosis syndrome.

Authors:  Amaan Ali; Jan Stener Jørgensen; Ronald F Lamont
Journal:  Fac Rev       Date:  2022-04-19

7.  Low-dose Nicotine Exposure Induced the Oxidative Damage of Reproductive Organs and Altered the Sperm Characteristics of Adolescent Male Rats.

Authors:  Siti Balkis Budin; Jia Hui Kho; Jia Hui Lee; Anand Ramalingam; Fatin Farhana Jubaidi; Elda Surhaida Latif; Satirah Zainalabidin; Izatus Shima Taib; Jamaludin Mohamed
Journal:  Malays J Med Sci       Date:  2017-12-29

8.  Lipid Peroxidation and Nitric Oxide Levels in Male Smokers' Spermatozoa and their Relation with Sperm Motility.

Authors:  Mohammad Ali Ghaffari; Morad Rostami
Journal:  J Reprod Infertil       Date:  2012-04

Review 9.  Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.

Authors:  Robert E Chapin; Wendie A Robbins; Laura A Schieve; Anne M Sweeney; Sonia A Tabacova; Kay M Tomashek
Journal:  Environ Health Perspect       Date:  2004-01       Impact factor: 9.031

10.  The effect of cigarette smoking on human sperm creatine kinase activity: as an ATP buffering system in sperm.

Authors:  Mohammad Ali Ghaffari; Morad Rostami
Journal:  Int J Fertil Steril       Date:  2013-03-03
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