Literature DB >> 824715

Naturally occurring polymers of IgA lacking J chain.

T B Tomasi, D S Czerwinski.   

Abstract

Two of twenty IgA myeloma proteins studied were found to lack J chain. Both IgA proteins contained dimers and higher polymers (trimers, tetramers, pentamers) in proportions similar to those found in most classical 'J-positive' proteins. Both the 'J-negative' proteins contained bound albumin and alpha-1 antitrypsin (alpha1AT),and reduction with mercaptoethylamine caused a release of albumin and alpha1AT concomitant with depolymerization of the higher polymers of IgA. These proteins formed complexes with secretory component (SC) in vitro, indicating that the presence of J chain is not a requirement for SC binding.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 824715     DOI： 10.1111/j.1365-3083.1976.tb03014.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  9 in total

1.  In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells.

Authors:  J Berdoz; C T Blanc; M Reinhardt; J P Kraehenbuhl; B Corthésy
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

2.  Lack of SC/pIgR-mediated epithelial transport of a human polymeric IgA devoid of J chain: in vitro and in vivo studies.

Authors:  J P Vaerman; A Langendries; D Giffroy; P Brandtzaeg; K Kobayashi
Journal:  Immunology       Date:  1998-09       Impact factor: 7.397

Review 3.  Transport models for secretory IgA and secretory IgM.

Authors:  P Brandtzaeg
Journal:  Clin Exp Immunol       Date:  1981-05       Impact factor: 4.330

4.  Increased dimeric IgA-producing B cells in tonsils in IgA nephropathy determined by in situ hybridization for J chain mRNA.

Authors:  S J Harper; A C Allen; M C Béné; J H Pringle; G Faure; I Lauder; J Feehally
Journal:  Clin Exp Immunol       Date:  1995-09       Impact factor: 4.330

5.  Reactive and neoplastic human lymphoid cells producing J chain in the absence of immunoglobulin: evidence for the existence of 'J chain disease'?

Authors:  D Y Mason; H Stein
Journal:  Clin Exp Immunol       Date:  1981-11       Impact factor: 4.330

6.  Presence of J chain in human lymphoid cells.

Authors:  J Mestecky; J L Preud'homme; S S Crago; E Mihaesco; J T Prchal; A J Okos
Journal:  Clin Exp Immunol       Date:  1980-02       Impact factor: 4.330

7.  J chain biosynthesis in pre-B cells and other possible precursor B cells.

Authors:  J M McCune; S M Fu; H G Kunkel
Journal:  J Exp Med       Date:  1981-07-01       Impact factor: 14.307

8.  Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins.

Authors:  S S Crago; R Kulhavy; S J Prince; J Mestecky
Journal:  J Exp Med       Date:  1978-06-01       Impact factor: 14.307

9.  Altered hepatic transport of immunoglobulin A in mice lacking the J chain.

Authors:  B A Hendrickson; D A Conner; D J Ladd; D Kendall; J E Casanova; B Corthesy; E E Max; M R Neutra; C E Seidman; J G Seidman
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.