Literature DB >> 8246244

Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.

C Melchiorre1, M L Bolognesi, A Chiarini, A Minarini, S Spampinato.   

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Year:  1993        PMID: 8246244     DOI: 10.1021/jm00075a032

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  5 in total

1.  Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines.

Authors:  R Budriesi; S Cacciaguerra; R D Toro; M L Bolognesi; A Chiarini; A Minarini; M Rosini; S Spampinato; V Tumiatti; C Melchiorre
Journal:  Br J Pharmacol       Date:  2001-03       Impact factor: 8.739

2.  Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells.

Authors:  David C Hornigold; Rajendra Mistry; Pamela D Raymond; Jonathan L Blank; R A John Challiss
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

3.  Characterization of the interaction between muscarinic M2 receptors and beta-adrenoceptor subtypes in guinea-pig isolated ileum.

Authors:  H Reddy; N Watson; A P Ford; R M Eglen
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

4.  Selective blockade of muscarinic M2 receptors in vivo by the new antagonist tripitramine.

Authors:  P Angeli; F Cantalamessa; U Gulini; C Melchiorre
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-09       Impact factor: 3.000

5.  In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors.

Authors:  A Chiarini; R Budriesi; M L Bolognesi; A Minarini; C Melchiorre
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

  5 in total

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