Literature DB >> 824455

Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells.

C W Song, J J Clement, S H Levitt.   

Abstract

5-Thio-D-glucose effectively killed hypoxic mastocytoma cells of DBA/2J mice, whereas it merely suppressed the growth of oxic cells. This specific toxicity suggested that 5-thio-D-glucose may be a useful adjuvant to radiotherapy by eliminating hypoxic protection.

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Year:  1976        PMID: 824455     DOI: 10.1093/jnci/57.3.603

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN: 0027-8874            Impact factor:   13.506


  11 in total

Review 1.  Alternative fuels for cancer cells.

Authors:  Melissa M Keenan; Jen-Tsan Chi
Journal:  Cancer J       Date:  2015 Mar-Apr       Impact factor: 3.360

2.  Expression and role in glycolysis of human ADP-dependent glucokinase.

Authors:  Susan Richter; Jan P Richter; Sunali Y Mehta; Amanda M Gribble; Andrew J Sutherland-Smith; Kathryn M Stowell; Cristin G Print; Ron S Ronimus; William R Wilson
Journal:  Mol Cell Biochem       Date:  2012-01-05       Impact factor: 3.396

3.  Cytotoxic effect of 5-thio-D-glucose on chronically hypoxic cells in multicell spheroids.

Authors:  C W Song; J H Sung; J J Clement; S H Levitt
Journal:  Br J Cancer Suppl       Date:  1978-06

4.  Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemia.

Authors:  Nicole M Sanders; Gerald J Taborsky; Charles W Wilkinson; Wendi Daumen; Dianne P Figlewicz
Journal:  Diabetes       Date:  2007-01       Impact factor: 9.461

Review 5.  Targeting hypoxia in cancer therapy.

Authors:  William R Wilson; Michael P Hay
Journal:  Nat Rev Cancer       Date:  2011-06       Impact factor: 60.716

6.  Cytotoxicity of glucose analogues in V79 multicell spheroids.

Authors:  R Sridhar; E C Stroude; W R Inch
Journal:  In Vitro       Date:  1979-09

7.  Cell survival in V79 multicell spheroids treated with dehydroascorbate, 5-thio-D-glucose and 2-deoxy-D-glucose.

Authors:  R Sridhar; C J Koch; E C Stroude; W R Inch
Journal:  Br J Cancer Suppl       Date:  1978-06

Review 8.  Targeting the metabolic microenvironment of tumors.

Authors:  Kate M Bailey; Jonathan W Wojtkowiak; Arig Ibrahim Hashim; Robert J Gillies
Journal:  Adv Pharmacol       Date:  2012

9.  Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions.

Authors:  I Tannock; P Guttman
Journal:  Br J Cancer       Date:  1981-02       Impact factor: 7.640

10.  HDAC6 inhibitors sensitize non-mesenchymal triple-negative breast cancer cells to cysteine deprivation.

Authors:  Tahiyat Alothaim; Morgan Charbonneau; Xiaohu Tang
Journal:  Sci Rep       Date:  2021-05-26       Impact factor: 4.379

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