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Literature DB >> 8244402

Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere.

Abstract

The chromosomal location of the gene SGLT2, which is presumed to encode a low-affinity Na+/glucose cotransporter, has been determined using a panel of rodent-human somatic cell hybrids. Southern blot analysis of genomic DNA from 16 different hybrids shows that SGLT2 is located on chromosome 16. Analysis of three additional hybrids that selectively retain all or part of human chromosome 16 demonstrates that SGLT2 is located close to the centromere in band p11.2 of the chromosome.

Entities: Gene Species

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Year: 1993 PMID： 8244402 DOI： 10.1006/geno.1993.1411

Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736

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Cited

16 in total

1. Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients.

Authors: Lei Yu; Ji-Cheng Lv; Xu-jie Zhou; Li Zhu; Ping Hou; Hong Zhang
Journal: Hum Genet Date: 2010-12-17 Impact factor: 4.132

2. Familial infantile convulsions and paroxysmal choreoathetosis: a new neurological syndrome linked to the pericentromeric region of human chromosome 16.

Authors: P Szepetowski; J Rochette; P Berquin; C Piussan; G M Lathrop; A P Monaco
Journal: Am J Hum Genet Date: 1997-10 Impact factor: 11.025

3. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

Authors: Y Kanai; W S Lee; G You; D Brown; M A Hediger
Journal: J Clin Invest Date: 1994-01 Impact factor: 14.808

4. Characterization of glucose transport by cultured rabbit kidney proximal convoluted and proximal straight tubule cells.

Authors: Pedro L Del Valle; Anna Trifillis; Charles E Ruegg; Andrew S Kane
Journal: In Vitro Cell Dev Biol Anim Date: 2002-04 Impact factor: 2.416

10. A recurrent deletion in the SLC5A2 gene including the intron 7 branch site responsible for familial renal glucosuria.

Authors: Xiangzhong Zhao; Li Cui; Yanhua Lang; Ting Liu; Jingru Lu; Cui Wang; Sylvie Tuffery-Giraud; Irene Bottillo; Xinsheng Wang; Leping Shao
Journal: Sci Rep Date: 2016-09-26 Impact factor: 4.379

Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere.

1. Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients.

2. Familial infantile convulsions and paroxysmal choreoathetosis: a new neurological syndrome linked to the pericentromeric region of human chromosome 16.

3. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

4. Characterization of glucose transport by cultured rabbit kidney proximal convoluted and proximal straight tubule cells.

5. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16.

6. SGLT2 promotes cardiac fibrosis following myocardial infarction and is regulated by miR-141.

Review 7. Patient profiling in diabetes and role of canagliflozin.

8. Decreased expression and function of sodium-glucose co-transporter 2 from a novel C-terminal mutation: a case report.

9. Novel SLC5A2 mutation contributes to familial renal glucosuria: Abnormal expression in renal tissues.

10. A recurrent deletion in the SLC5A2 gene including the intron 7 branch site responsible for familial renal glucosuria.