Literature DB >> 8243562

Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats.

Y Ishiyama1, K Kitamura, Y Ichiki, S Nakamura, O Kida, K Kangawa, T Eto.   

Abstract

The hemodynamic effects of human adrenomedullin were investigated in anesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressure associated with a decrease in total peripheral resistance. This reduction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.

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Year:  1993        PMID： 8243562     DOI： 10.1016/0014-2999(93)90214-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  34 in total

1.  Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein.

Authors:  Kavin G Shah; Derry Rajan; Asha Jacob; Rongqian Wu; Kambhampaty Krishnasastry; Jeffrey Nicastro; Ernesto P Molmenti; Gene F Coppa; Ping Wang
Journal:  J Surg Res       Date:  2010-04-24       Impact factor: 2.192

Review 2.  Mid-regional pro-adrenomedullin in acute heart failure: a better biomarker or just another biomarker?

Authors:  Mihael Potocki; Ronny Ziller; Christian Mueller
Journal:  Curr Heart Fail Rep       Date:  2012-09

Review 3.  Novel neurohumoral factors in congestive heart failure: adrenomedullin.

Authors:  J G Lainchbury
Journal:  Curr Cardiol Rep       Date:  2001-05       Impact factor: 2.931

4.  Effects of adrenomedullin and calcitonin gene-related peptide on airway and pulmonary vascular smooth muscle in guinea-pigs.

Authors:  A Pinto; K Sekizawa; M Yamaya; T Ohrui; Y X Jia; H Sasaki
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

Review 5.  Adrenomedullin. Implications for hypertension research.

Authors:  K Kitamura; K Kangawa; H Matsuo; T Eto
Journal:  Drugs       Date:  1995-04       Impact factor: 9.546

6.  Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure.

Authors:  T Ishimitsu; T Nishikimi; Y Saito; K Kitamura; T Eto; K Kangawa; H Matsuo; T Omae; H Matsuoka
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

7.  Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissue.

Authors:  H Washimine; Y Asada; K Kitamura; Y Ichiki; S Hara; Y Yamamoto; K Kangawa; A Sumiyoshi; T Eto
Journal:  Histochem Cell Biol       Date:  1995-04       Impact factor: 4.304

Review 8.  Adrenomedullin and diabetes.

Authors:  Hoi Kin Wong; Fai Tang; Tsang Tommy Cheung; Bernard Man Yung Cheung
Journal:  World J Diabetes       Date:  2014-06-15

9.  Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion.

Authors:  Juntao Yang; Rongqian Wu; Xiaoling Qiang; Mian Zhou; Weifeng Dong; Youxin Ji; Corrado P Marini; Thanjavur S Ravikumar; Ping Wang
Journal:  Ann Surg       Date:  2009-02       Impact factor: 12.969

10.  Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.

Authors:  X Wang; T L Yue; F C Barone; R F White; R K Clark; R N Willette; A C Sulpizio; N V Aiyar; R R Ruffolo; G Z Feuerstein
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205
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