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Literature DB >> 8241771

Evolution and role of Pax genes.

Abstract

Pax genes encode a class of highly conserved transcription factors containing a paired-domain. These factors play important roles in Drosophila and vertebrate development, for example, in segmentation and neurogenesis. Their developmental roles are assessed in terms of their participation in conserved gene networks and mechanisms that establish positional information.

Entities: Gene Species

Mesh：

Substances：
DNA-Binding Proteins

Year: 1993 PMID： 8241771 DOI： 10.1016/0959-437x(93)90095-7

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

79 in total

1. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.

Authors: D Eberhard; G Jiménez; B Heavey; M Busslinger
Journal: EMBO J Date: 2000-05-15 Impact factor: 11.598

2. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.

Authors: M S Lechner; I Levitan; G R Dressler
Journal: Nucleic Acids Res Date: 2000-07-15 Impact factor: 16.971

3. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.

Authors: H E Xu; M A Rould; W Xu; J A Epstein; R L Maas; C O Pabo
Journal: Genes Dev Date: 1999-05-15 Impact factor: 11.361

Evolution and role of Pax genes.

1. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.

2. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.

3. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.

4. The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2.

5. WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8.

Review 6. Building muscle: molecular regulation of myogenesis.

Review 7. Evolution of centralized nervous systems: two schools of evolutionary thought.

8. Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker.

9. Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter.

10. Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina.