Literature DB >> 824156

The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat.

L Manzo, R Passoni, A D Segre, F Berte, A Crema.   

Abstract

Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidative N-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde.

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Year:  1976        PMID： 824156     DOI： 10.1007/BF01953115

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Enzymatic dealkylation of aminopyrine (pyramidon) and other alkylamines.

Authors:  B N LA DU; L GAUDETTE; N TROUSOF; B B BRODIE
Journal:  J Biol Chem       Date:  1955-06       Impact factor: 5.157

2.  Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.

Authors:  J COCHIN; J AXELROD
Journal:  J Pharmacol Exp Ther       Date:  1959-02       Impact factor: 4.030

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Inhibition of some rat hepatic microsomal enzymes by ethoxyquin.

Authors:  D V Parke; A Rahim; R Walker
Journal:  Biochem Pharmacol       Date:  1974-12-15       Impact factor: 5.858

5.  [Clinical research on the therapeutic use of orthoxyquinoline sulfonate of dimethyl-diphenyl-amino-isopyrazolone in association with vitamins B 6 and B 12].

Authors:  M Gorini; A Fattorini
Journal:  Minerva Med       Date:  1967-03-03       Impact factor: 4.806

6.  [Skin absorption of ortho-oxyquinolinsulfate of aminophenazone].

Authors:  P L Rugarli; R Passoni; A D Segre; A Crema
Journal:  Boll Chim Farm       Date:  1974-09

7.  Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit.

Authors:  T E Gram; J T Wilson; J R Fouts
Journal:  J Pharmacol Exp Ther       Date:  1968-01       Impact factor: 4.030

8.  The rate-limiting step in the biliary elimination of some substrates of uridine diphosphate glucuronyltransferase in the rat.

Authors:  G J Mulder
Journal:  Biochem Pharmacol       Date:  1973-07-15       Impact factor: 5.858
  8 in total
  1 in total

1.  Aminopyrine: metabolism and effects in the rat after administration of inhibitors of hepatic monooxygenases.

Authors:  A Di Nucci; P L Rugarli; B Ferrini; A Tarozzi; C Gregotti; L Manzo
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1979       Impact factor: 2.441
  1 in total

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