Literature DB >> 8241349

Spontaneous IL-2 production in vitro in two patients with pure red cell aplasia.

T Ishiyama1, Y Akimoto, H Ueno, K Kawakami, M Koike, S Tomoyasu, N Tsuruoka.   

Abstract

We investigated spontaneous cytokine production in two patients with pure red cell aplasia (PRCA). The peripheral blood mononuclear cells (PBMNC) from two patients produced IL-2. Cyclosporin A (CyA) suppressed in vitro IL-2 production in one patient, but not in the other. Spontaneous IL-2 production disappeared in one patient 10 months after the start of CyA therapy. The patient for whom CyA therapy was stopped after the disappearance of spontaneous IL-2 production has remained in continuous remission for 1 year. The present case suggests that spontaneous IL-2 production in PBMNC might be an indicator of disease activity.

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Year:  1993        PMID： 8241349     DOI： 10.1007/bf01715056

Source DB:  PubMed          Journal:  Ann Hematol        ISSN： 0939-5555            Impact factor:   3.673


  8 in total

1.  Acquired erythrocytic hypoplasia: a recovery during cobalt therapy; report of two cases with review of the literature.

Authors:  A J SEAMAN; R D KOLER
Journal:  Acta Haematol       Date:  1953-03       Impact factor: 2.195

2.  Gamma-interferon in aplastic anemia: inability to detect significant levels in sera or demonstrate hematopoietic suppressing activity.

Authors:  B Torok-Storb; G G Johnson; R Bowden; R Storb
Journal:  Blood       Date:  1987-02       Impact factor: 22.113

Review 3.  Cyclosporin A: recent developments in the mechanism of action and clinical application.

Authors:  G Feutren
Journal:  Curr Opin Immunol       Date:  1989-12       Impact factor: 7.486

4.  Successful treatment of pure red-cell aplasia with cyclosporin.

Authors:  T H Tötterman; J Nisell; A Killander; G Gahrton; B Lönnqvist
Journal:  Lancet       Date:  1984-09-22       Impact factor: 79.321

Review 5.  Pure red cell aplasia: review of treatment and proposal for a treatment strategy.

Authors:  A Raghavachar
Journal:  Blut       Date:  1990 Aug-Sep

6.  The influence of cyclosporin A on the alternative pathways of human T cell activation in vitro.

Authors:  E Bloemena; R H Van Oers; S Weinreich; A P Stilma-Meinesz; P T Schellekens; R A Van Lier
Journal:  Eur J Immunol       Date:  1989-05       Impact factor: 5.532

7.  Treatment of refractory pure red cell aplasia with cyclosporine A: disappearance of IgG inhibitor associated with clinical response.

Authors:  R T Means; E N Dessypris; S B Krantz
Journal:  Br J Haematol       Date:  1991-05       Impact factor: 6.998

8.  Treatment of pure red-cell aplasia and aplastic anaemia with ciclosporin: long-term clinical effects.

Authors:  T H Tötterman; M Höglund; M Bengtsson; B Simonsson; D Almqvist; A Killander
Journal:  Eur J Haematol       Date:  1989-02       Impact factor: 2.997
  8 in total

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