Literature DB >> 824069

The inhibition of allergen induced bronchospasm in man by oral BRL 10833.

R Pauwels, H Lamont, M Van der Straeten.   

Abstract

BRL 10833, a nitroindanedione, with DSCG like activity in rat immediate type hypersensitivity, shows good absorption after oral intake in man. The ingestion of 2 and 10 mg BRL 10833/kg body weight provides protection against the immediate type allergen induced bronchoconstriction in patients with bronchial asthma. These results confirm the activity of the drug shown by inhalation.

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Year:  1976        PMID: 824069     DOI: 10.1111/j.1365-2222.1976.tb01931.x

Source DB:  PubMed          Journal:  Clin Allergy        ISSN: 0009-9090


  1 in total

1.  The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils.

Authors:  E M Lumb; G J McHardy; A B Kay
Journal:  Br J Clin Pharmacol       Date:  1979-07       Impact factor: 4.335

  1 in total

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