OBJECTIVE: Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. METHODS: Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. RESULTS: Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice. CONCLUSION: PC appears to inhibit disease progression in murine progressive ankylosis.
OBJECTIVE:Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. METHODS: Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. RESULTS: Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice. CONCLUSION:PC appears to inhibit disease progression in murineprogressive ankylosis.
Authors: Cornelia D Cudrici; Kam A Newman; Elisa A Ferrante; Rebecca Huffstutler; Katherine Carney; Blas Betancourt; Markku Miettinen; Richard Siegel; James D Katz; Leon J Nesti; Cynthia St Hilaire; Deepak Lakshmipathy; Han Wen; Mohammad H Bagheri; Manfred Boehm; Alessandra Brofferio Journal: Rheumatology (Oxford) Date: 2021-12-24 Impact factor: 7.580