Cocaine self-injection behaviour under schedules of delayed reinforcement in monkeys.

Rates of lever pressing, maintained either by response-dependent intravenous injections of cocaine (250 mug/kg per injection) or by food-pellet presentation, were compared and found to vary systematically as a function of the delay (5-100 s) imposed between the response(s) and the occurrence of reinforcement. The control of responding by two schedules of delayed reinforcement was studied. The first scedule permitted responses to occur during the delay period without any programmed consequence; the second schedule required a response, and then the elapse of x seconds without any additional response(s). At imposed delays of 50 and 100 s, response rates were reduced significantly when the second schedule was in effect by comparison with the first. The effect was observed when responding was maintained either by intravenous cocaine injections or by food-pellet presentation. Across all comparable conditions, response rates were higher when maintained by scheduled cocaine injections than by food pellets. Rate enhancement, generally induced by drugs of the psychomotor stimulant type, could account for the observed difference.