Literature DB >> 8240264

Does phosphoglucoisomerase display anomeric specificity or selectivity towards alpha-D-glucose 6-phosphate? An assessment by two-dimensional phase-sensitive 31P exchange spectroscopy (EXSY) n.m.r.

F Kayser1, M Biesemans, R Willem, F Malaisse-Lagae, W J Malaisse.   

Abstract

The study by two-dimensional phase-sensitive 31P exchange spectroscopy (EXSY) n.m.r. of hexose 6-phosphates interconversion in the reaction catalysed by yeast phosphoglucoisomerase reveals that the enzyme displays anomeric selectivity, rather than specificity, towards alpha-D-glucose 6-phosphate. Indeed, beta-D-glucose 6-phosphate participates for about 20% to the total and direct conversion of the aldohexose into oxohexose ester.

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Year:  1993        PMID： 8240264      PMCID： PMC1134924          DOI： 10.1042/bj2950607

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  SPONTANEOUS AND ENZYMATICALLY CATALYZED ANOMERIZATION OF GLUCOSE 6-PHOSPHATE AND ANOMERIC SPECIFICITY OF RELATED ENZYMES.

Authors:  M SALAS; E VINUELA; A SOLS
Journal:  J Biol Chem       Date:  1965-02       Impact factor: 5.157

Review 2.  Metabolism and disorders of the endocrine pancreas.

Authors:  W J Malaisse; R Willem; F Malaisse-Lagae; D Zähner; V Leclercq-Meyer; A Sener
Journal:  Acta Radiol Suppl       Date:  1990

3.  Anomeric specificity of D-glucose metabolism in rat adipocytes.

Authors:  F Malaisse-Lagae; W J Malaisse
Journal:  Eur J Biochem       Date:  1986-08-01

4.  Determination of the kinetic constants of glucosephosphate isomerase by non-linear optimization. Isomerization and anomerization function.

Authors:  T Plesser; B Wurster; B Hess
Journal:  Eur J Biochem       Date:  1979-07

5.  Catalytic reactions of phosphoglucose isomerase with cyclic forms of glucose 6-phosphate and fructose 6-phosphate.

Authors:  K J Schray; S J Benkovic; P A Benkovic; I A Rose
Journal:  J Biol Chem       Date:  1973-03-25       Impact factor: 5.157

6.  Anomeric specificity of glucose metabolism in the pentose cycle.

Authors:  W J Malaisse; M H Giroix; A Sener
Journal:  J Biol Chem       Date:  1985-11-25       Impact factor: 5.157

7.  Rates of enzyme-catalyzed exchange determined by two-dimensional NMR: a study of glucose 6-phosphate anomerization and isomerization.

Authors:  R S Balaban; J A Ferretti
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

8.  Stimulus-secretion coupling of glucose-induced insulin release. Metabolism of alpha- and beta-D-glucose in isolated islets.

Authors:  W J Malaisse; A Sener; M Koser; A Herchuelz
Journal:  J Biol Chem       Date:  1976-10-10       Impact factor: 5.157

9.  Dual anomeric specificity and dual anomerase activity of phosphoglucoisomerase quantified by two-dimensional phase-sensitive 13C EXSY NMR.

Authors:  R Willem; M Biesemans; K Hallenga; G Lippens; F Malaisse-Lagae; W J Malaisse
Journal:  J Biol Chem       Date:  1992-01-05       Impact factor: 5.157
  9 in total

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