Literature DB >> 8240002

Histamine and 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline are competitive inhibitors of debrisoquine 4-monooxygenase in rat liver.

K Iwahashi1, Y Matsuo, Y Tsuneoka, Y Ichikawa, K Hosokawa, H Suwaki.   

Abstract

The effects of histamine and 1-methyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline(salsolinol) on debrisoquine 4-monooxygenation, which is catalyzed by cytochrome P-450db 1 (CYP2D1) in rat liver microsomes, were studied. Both histamine and salsolinol competitively inhibited the activity of debrisoquine 4-monooxygenase (Ki = 0.31 and 0.43 mM, respectively). These data demonstrate that histamine and salsolinol bind to the active site of CYP2D1, i.e. histamine and salsolinol have structures (molecular shape) corresponding to the active site of CYP2D1.

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Year:  1993        PMID： 8240002     DOI： 10.1007/bf01969924

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  Enzymatic hydroxylation of aromatic compounds.

Authors:  C MITOMA; H S POSNER; H C REITZ; S UDENFRIEND
Journal:  Arch Biochem Biophys       Date:  1956-04       Impact factor: 4.013

2.  Debrisoquine 4-monooxygenase and bufuralol 1'-monooxygenase activities in bovine and rabbit tissues.

Authors:  Y Matsuo; K Iwahashi; Y Ichikawa
Journal:  Biochem Pharmacol       Date:  1992-05-08       Impact factor: 5.858

3.  Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism.

Authors:  R Fonne-Pfister; U A Meyer
Journal:  Biochem Pharmacol       Date:  1988-10-15       Impact factor: 5.858

4.  Histamine: an inhibitor of cytochrome P-450-catalysed drug metabolism.

Authors:  M S Lennard; H K Crewe; G T Tucker; H F Woods
Journal:  Biochem Pharmacol       Date:  1986-08-01       Impact factor: 5.858

5.  Solubilization, characterization and partial purification of [3H]mepyramine-binding protein, a possible histamine H1 receptor, from rat liver membrane.

Authors:  H Fukui; N P Wang; T Watanabe; H Wada
Journal:  Jpn J Pharmacol       Date:  1988-02

6.  Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.

Authors:  R N Kalaria; M J Mitchell; S I Harik
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

7.  Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver.

Authors:  C Q Morris; G T Tucker; H K Crewe; J R Harlow; H F Woods; M S Lennard
Journal:  Biochem Pharmacol       Date:  1989-08-15       Impact factor: 5.858

8.  High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.

Authors:  T Kronbach; D Mathys; J Gut; T Catin; U A Meyer
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

Review 9.  The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

Authors:  D W Nebert; D R Nelson; M J Coon; R W Estabrook; R Feyereisen; Y Fujii-Kuriyama; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson
Journal:  DNA Cell Biol       Date:  1991 Jan-Feb       Impact factor: 3.311
  9 in total
  1 in total

Review 1.  Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments.

Authors:  Magdalena Kurnik-Łucka; Pertti Panula; Andrzej Bugajski; Krzysztof Gil
Journal:  Neurotox Res       Date:  2017-10-23       Impact factor: 3.911
  1 in total

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