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Literature DB >> 8239630

Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.

Y Yoshiyama¹, S Nishikawa, T Sugiyama, T Kobayashi, H Shimada, F Tomonaga, S Ohdo, N Ogawa, S Nakano.

Abstract

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

Entities: Chemical Disease Species

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Year: 1993 PMID： 8239630 PMCID： PMC188120 DOI： 10.1128/AAC.37.9.2042

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

4 in total

1. Chronotoxical study of gentamicin induced nephrotoxicity in rats.

Authors: Y Yoshiyama; T Kobayashi; F Tomonaga; S Nakano
Journal: J Antibiot (Tokyo) Date: 1992-05 Impact factor: 2.649

2. Circadian variation in serum amikacin levels.

Authors: L Elting; G P Bodey; B Rosenbaum; V Fainstein
Journal: J Clin Pharmacol Date: 1990-09 Impact factor: 3.126

Review 3. Once-daily aminoglycoside administration: new strategies for an old drug.

Authors: J M Kovarik; I M Hoepelman; J Verhoef
Journal: Eur J Clin Microbiol Infect Dis Date: 1989-09 Impact factor: 3.267

4. Comparative nephrotoxicity of SCH 21420 and amikacin in rats.

Authors: L I Rankin; F C Luft; M N Yum; R S Sloan; C B Dinwiddie; L L Isaacs
Journal: Antimicrob Agents Chemother Date: 1979-10 Impact factor: 5.191

4 in total

8 in total

1. Effectiveness and toxicity of gentamicin in an experimental model of pyelonephritis: effect of the time of administration.

Authors: M LeBrun; L Grenier; P Gourde; M G Bergeron; G Labrecque; D Beauchamp
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.

1. Chronotoxical study of gentamicin induced nephrotoxicity in rats.

2. Circadian variation in serum amikacin levels.

Review 3. Once-daily aminoglycoside administration: new strategies for an old drug.

4. Comparative nephrotoxicity of SCH 21420 and amikacin in rats.

1. Effectiveness and toxicity of gentamicin in an experimental model of pyelonephritis: effect of the time of administration.

2. Pharmacologic Basis for the Treatment of Pyelonephritis.

3. Time-restricted feeding schedules modify temporal variation of gentamicin experimental nephrotoxicity.

4. Pharmacokinetic and pharmacodynamic approach for comparing two therapeutic regimens using amikacin.

5. Chronopharmacokinetics of once daily dosed aminoglycosides in hospitalized infectious patients.

6. Effects of fasting on temporal variations in nephrotoxicity of gentamicin in rats.

7. Temporal variation in nephrotoxicity of low doses of isepamicin in rats.

8. Daily variations in ceftriaxone pharmacokinetics in rats.