| Literature DB >> 8239514 |
Y Ochi1, S Atsumi, T Aoyagi, K Umezawa.
Abstract
An alpha-mannosidase inhibitor, mannostatin A, from Streptoverticillium verticillus var. quintum inhibited chemotactic invasion of mouse B16/F10 melanoma cells in the Boyden chamber assay. It also inhibited in vitro invasion of K-ras-NIH3T3 cells. Mannostatin A did not inhibit the growth of either cell line at the concentration effective to inhibit invasion. Addition of mannostatin A to the cultured B16/F10 or K-ras-NIH3T3 cells inhibited cellular alpha-mannoside activity specifically. Mannostatin A-treated B16/F10 cells also showed decreased metastatic activity in vivo in C57Bl/6 mice.Entities:
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Year: 1993 PMID： 8239514
Source DB: PubMed Journal: Anticancer Res ISSN： 0250-7005 Impact factor: 2.480